EXOC5 and IFT57

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EXOC5	IFT57
Description		exocyst complex component 5	intraflagellar transport 57
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Midbody	Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytoskeleton Cilium Axoneme Intraciliary Transport Particle B Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Dendrite Terminus Ciliary Tip Ciliary Base
	Molecular Function	Protein Binding Small GTPase Binding	DNA Binding Protein Binding
	Biological Process	Mitotic Cytokinesis Establishment Of Planar Polarity Exocytosis Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Protein Localization To Plasma Membrane Membrane Fission Vesicle Tethering Involved In Exocytosis Epithelial Cell Apoptotic Process Non-motile Cilium Assembly	Neural Tube Closure Heart Looping Apoptotic Process Smoothened Signaling Pathway Negative Regulation Of Keratinocyte Proliferation Intraciliary Anterograde Transport Intraciliary Transport Regulation Of Apoptotic Process Keratinocyte Proliferation Motile Cilium Assembly Cilium Assembly Left/right Pattern Formation Non-motile Cilium Assembly
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Hedgehog 'off' state Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Chronotype ( 30696823) HDL cholesterol levels in HIV infection ( 33109212) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 31043756) Regular attendance at a religious group ( 29970889)
Interacting Genes		41 interacting genes: ACTR3B ADCK1 ARF6 BARD1 BRMS1L C1orf216 CCDC102B CDH2 CREBBP CRYBB1 DEUP1 DNAAF4 EDRF1 ENO2 FGA FRMD6 HDDC3 HGS ICA1 IFT57 KIFC3 MAGEA3 MAGEA6 OAS1 PRKCG PSTPIP1 PTK6 PYCARD RAB14 RAB4A RAB4B RALA SOX10 SPACA9 TBX21 THOC1 TNPO2 TTC23L TXLNB TXNL4A USP2	8 interacting genes: EXOC5 HIP1 IFT20 SKA2 UBXN10 WASHC1 YAF2 ZDHHC17
Entrez ID		10640	55081
HPRD ID		07258	09430
Ensembl ID		ENSG00000070367	ENSG00000114446
Uniprot IDs		O00471	Q9NWB7
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein Activity GDP Binding Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Membrane GTPase Activity Early Endosome Membrane Regulation Of Endocytosis Insulin-responsive Compartment	Protein Transport Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Intracellular Protein Localization Cytoplasmic Vesicle Exocyst Cellular Localization Establishment Of Localization In Cell Intraciliary Transport Particle B Clathrin Coat Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Establishment Of Planar Polarity Organelle Assembly Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Intracellular Transport Centriole Cytoplasmic Vesicle Membrane Positive Regulation Of Cilium Assembly Cytoskeleton Regulation Of Cell Projection Assembly Establishment Of Spindle Orientation Phosphate:proton Symporter Activity Mitochondrial Phosphate Ion Transmembrane Transport TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Perforant Pathway To Dendrate Granule Cell Synapse Establishment Of Spindle Localization Spindle Localization Cilium Assembly Cellular Component Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Presynaptic Endocytic Zone Membrane Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Cilium Organization Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Opsin Transport Intraciliary Transport Particle Regulation Of Receptor Internalization Vesicle-mediated Transport Regulation Of Cellular Component Organization Clathrin-coated Vesicle Autophagosome
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