LUC7L3 and SRSF1

Number of citations of the paper that reports this interaction (PubMedID 12565863)
0

Data Source:
HPRD (two hybrid, in vitro)

		LUC7L3	SRSF1
Description		LUC7 like 3 pre-mRNA splicing factor	serine and arginine rich splicing factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Nuclear Speck U2-type Prespliceosome	Nucleus Nuclear Envelope Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Kinase B Binding DNA Topoisomerase Binding RS Domain Binding
	Biological Process	MRNA Splice Site Recognition MRNA Processing RNA Splicing	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing RNA Splicing Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of RNA Splicing Protein Localization To Nucleus Regulation Of RNA Splicing MRNA Stabilization Oligodendrocyte Differentiation MRNA Transport Cardiac Muscle Contraction Cellular Response To Interleukin-17 Interleukin-17-mediated Signaling Pathway Liver Regeneration Protein Localization To P-body
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs			Copper
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Mild to moderate chronic kidney disease ( 31178898)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		12 interacting genes: CLK1 ITSN2 MLH1 OGT RNPS1 SRPK1 SRPK2 SRSF1 TLR10 TXNIP USP7 YWHAG	53 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK13 CDK6 CDR1 CLK1 CLK2 CLK3 CLK4 CPSF7 DANCR DIDO1 DYRK1A FOXP1 GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L LUC7L3 NFYA NXF1 PPARG PRKN PRMT1 PRP4K PRPF4 PSIP1 RNF10 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		51747	6426
HPRD ID		16759	02887
Ensembl ID		ENSG00000108848	ENSG00000136450
Uniprot IDs		A8K3C5 J3KPP4 O95232 Q86Y74	Q07955 Q59FA2
PDB IDs			1X4A 2M7S 2M8D 2O3D 3BEG 4C0O 6HPJ 7ABG 8QO9
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing TORC1 Signaling TOR Signaling MRNA Metabolic Process Regulation Of TORC1 Signaling Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Exon-exon Junction Complex RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of TOR Signaling Nuclear Speck MRNA Processing Positive Regulation Of Viral Genome Replication Response To Stress Protein-RNA Complex Assembly Regulation Of Macromolecule Metabolic Process Signal Transduction Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Gene Expression Cellular Response To Nutrient Levels Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Organelle Protein Localization To Lysosome Regulation Of Metabolic Process Positive Regulation Of Viral Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Chromosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment	MRNA Metabolic Process RNA Splicing MRNA Processing Nuclear Speck RNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Nucleus Protein-RNA Complex Assembly RNA Binding RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of MRNA Processing Protein Serine/threonine Kinase Activity MRNA Splicing, Via Spliceosome Protein Serine Kinase Activity MRNA Splice Site Recognition Nucleic Acid Binding Protein-containing Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex MRNA Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Protein-containing Complex Organization Negative Regulation Of RNA Splicing Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of RNA Metabolic Process Regulation Of Gene Expression U2-type Prespliceosome Regulation Of Macromolecule Biosynthetic Process Kinase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Pre-mRNA 3'-splice Site Binding RS Domain Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Protein Tyrosine Kinase Activity Identical Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
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