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DRAP1 and CDKN2C
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
DRAP1
CDKN2C
Gene Name
DR1-associated protein 1 (negative cofactor 2 alpha)
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleus
Cytoplasm
Cytosol
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Cell Cycle Arrest
Negative Regulation Of Cell Proliferation
Negative Regulation Of Cell Growth
Negative Regulation Of Phosphorylation
Oligodendrocyte Differentiation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Signaling by Activin
Signaling by NODAL
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
G1 Phase
Cellular Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Ventricular conduction (
21076409
)
Protein-Protein Interactions
22 interactors:
APP
ARHGEF10L
CDKN2C
DNAJB11
DR1
FEZ1
FEZ2
FOXH1
GTF2B
LMO2
NCK2
NFYB
PIK3R3
POLE3
SRPK2
TAF9
TAF9B
TBP
TK1
TNFRSF14
TTF2
ZEB1
27 interactors:
AHCYL1
APLP1
ATM
ATR
CCDC90B
CDK4
CDK6
CDKN2A
COPS6
DRAP1
GDF9
GOPC
LRIF1
LY96
MAPK10
MAPK8
NAGK
NHP2L1
NIF3L1
PPP2CA
RBM48
REL
TCF12
TCF4
TLE1
TP53
UNC119
Entrez ID
10589
1031
HPRD ID
03796
04534
Ensembl ID
ENSG00000175550
ENSG00000123080
Uniprot IDs
Q14919
P42773
Q6ICV4
PDB IDs
1JFI
1BU9
1G3N
1IHB
1MX2
1MX4
1MX6
Enriched GO Terms of Interacting Partners
?
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription Elongation From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Cellular Metabolic Process
DNA-templated Transcription, Elongation
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Transcription, DNA-templated
Gene Expression
Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Histone H3 Acetylation
Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Transcription From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Cellular Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Viral Process
Histone Acetylation
Regulation Of Receptor Activity
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Internal Protein Amino Acid Acetylation
Response To Organic Substance
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Protein Acetylation
Negative Regulation Of Transcription, DNA-templated
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Replicative Senescence
Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Signal Transduction
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Cell Cycle Arrest
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Process
Cell Aging
Positive Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Cell Cycle Arrest
Mitotic Cell Cycle Process
RNA Metabolic Process
Cell Cycle
Negative Regulation Of Growth
Regulation Of Intracellular Signal Transduction
Response To Radiation
Negative Regulation Of Cell Cycle
Regulation Of Signal Transduction
Signal Transduction
Mitotic Cell Cycle
JUN Phosphorylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Death
Positive Regulation Of Cell Aging
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Signaling
Negative Regulation Of Cell Growth
Response To Gamma Radiation
Regulation Of Signaling
Positive Regulation Of Cellular Metabolic Process
Response To Light Stimulus
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Apoptotic Process
Cell Communication
Positive Regulation Of Programmed Cell Death
Cellular Metabolic Process
Cellular Response To Ionizing Radiation
Positive Regulation Of Cell Death
Tagcloud
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Difference)
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Intersection)
?