DRAP1 and GTF2B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DRAP1	GTF2B
Gene Name		DR1-associated protein 1 (negative cofactor 2 alpha)	general transcription factor IIB
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Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	Core Promoter Binding Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process
Pathways		Signaling by Activin Signaling by NODAL	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		22 interactors: APP ARHGEF10L CDKN2C DNAJB11 DR1 FEZ1 FEZ2 FOXH1 GTF2B LMO2 NCK2 NFYB PIK3R3 POLE3 SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1	56 interactors: ATF4 BCL3 CIITA CREBBP CTBP1 DEPDC7 DHX9 DRAP1 EP300 ESR1 ESRRA FBXO25 FOXF2 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 HMGCL HNF4A HSF1 IKZF1 JAK3 JUN KLF5 MCM2 MECP2 MYC NCOA1 NCOA3 NCOA4 NCOR1 NOLC1 NR1D2 NR2F1 NR5A1 POLR2A POLR2E POU3F2 PSMC2 PSMC5 REL RELA REST SLC22A2 SRA1 TAF11 TAF9 TBP TBPL1 TCEA2 THRA TNIP1 TRAM2 VDR YWHAE
Entrez ID		10589	2959
HPRD ID		03796	08928
Ensembl ID		ENSG00000175550	ENSG00000137947
Uniprot IDs		Q14919	Q00403
PDB IDs		1JFI	1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Viral Process Histone Acetylation Regulation Of Receptor Activity Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Internal Protein Amino Acid Acetylation Response To Organic Substance Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Acetylation Negative Regulation Of Transcription, DNA-templated Regulation Of Epidermal Growth Factor-activated Receptor Activity	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression DNA-templated Transcription, Initiation Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Regulation Of Viral Transcription Response To Organic Substance Positive Regulation Of Viral Transcription Regulation Of Viral Process Cellular Response To Organic Substance Positive Regulation Of Viral Process Metabolic Process Steroid Hormone Mediated Signaling Pathway
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