DRAP1 and DR1

Number of citations of the paper that reports this interaction (PMID 8670811)
60

Data Source:
HPRD (in vitro, in vivo)

		DRAP1	DR1
Gene Name		DR1-associated protein 1 (negative cofactor 2 alpha)	down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Histone H3 Acetylation
Pathways		Signaling by Activin Signaling by NODAL	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP ARHGEF10L CDKN2C DNAJB11 DR1 FEZ1 FEZ2 FOXH1 GTF2B LMO2 NCK2 NFYB PIK3R3 POLE3 SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1	8 interactors: DRAP1 NFIL3 NFYC POLE3 TBP TTF2 XPO1 ZDHHC17
Entrez ID		10589	1810
HPRD ID		03796	03284
Ensembl ID		ENSG00000175550
Uniprot IDs		Q14919	Q01658 Q658N3
PDB IDs		1JFI	1JFI
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Viral Process Histone Acetylation Regulation Of Receptor Activity Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Internal Protein Amino Acid Acetylation Response To Organic Substance Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Acetylation Negative Regulation Of Transcription, DNA-templated Regulation Of Epidermal Growth Factor-activated Receptor Activity	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Termination Transcription, DNA-templated RNA Biosynthetic Process Pharynx Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Ribosomal Small Subunit Export From Nucleus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Soft Palate Development Transcription From RNA Polymerase II Promoter Ribosomal Large Subunit Export From Nucleus Nitrogen Compound Metabolic Process Ribosomal Subunit Export From Nucleus Hard Palate Development Chromatin Silencing At RDNA Thyroid Hormone Generation Lipoprotein Transport Magnesium Ion Transport Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Export From Nucleus Termination Of RNA Polymerase I Transcription Thyroid Hormone Metabolic Process Transcription Elongation From RNA Polymerase I Promoter Thyroid Gland Development Intracellular Transport Of Virus Transcription Initiation From RNA Polymerase I Promoter Protein Palmitoylation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase I Promoter
Tagcloud ?			cofactors conferred consensus cos cultured dr1d dr1p dr5 efficiently eighth harbors hcrabpii heterodimers heterologous homology insufficient kc keratinocytes nonfunctional rargamma responsiveness restored retinoid rxralpha share start supershift surprisingly
Tagcloud (Difference) ?			cofactors conferred consensus cos cultured dr1d dr1p dr5 efficiently eighth harbors hcrabpii heterodimers heterologous homology insufficient kc keratinocytes nonfunctional rargamma responsiveness restored retinoid rxralpha share start supershift surprisingly
Tagcloud (Intersection) ?