DRAP1 and PIK3R3

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		DRAP1	PIK3R3
Description		DR1 associated protein 1	phosphoinositide-3-kinase regulatory subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex	Cytosol Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA
	Molecular Function	Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Phosphotyrosine Residue Binding Protein Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II	Cell Migration Involved In Sprouting Angiogenesis Immune Response Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Anoikis
Pathways		Signaling by NODAL Signaling by Activin	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling RAC1 GTPase cycle RAC2 GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Co-stimulation by ICOS
Drugs			SF1126
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil percentage of granulocytes ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Severe influenza A (H1N1) infection ( 26379185)	Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Serum metabolite levels ( 33031748) Sodium levels ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		31 interacting genes: APP ARHGEF10L CDKN2C DNAJB11 DR1 FBXO7 FEZ1 FEZ2 FOXH1 GTF2B LMO2 LNX1 LNX2 MCRS1 MORF4L1 NCK2 NFYB PICK1 PIK3R3 PLEKHF2 POLE3 RPL9 SDCBP SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1	122 interacting genes: ABCB6 ABL2 AMBP ANKS1A ANTKMT AR ARID4B AUNIP AXL BLK BLZF1 BRK1 BTK C3orf36 CAMK1 CCDC14 CCDC196 CCDC33 CCDC89 CEP126 CEP19 CHRDL2 CIMIP2B CLNK CRBN CRK DARS1 DCAF8 DISC1 DRAP1 DSN1 E2F6 EGFR ENKD1 ERBB2 ERBB3 ERBB4 ESR1 FBN3 FER FGB FNDC8 FOXO1 FSD2 FYN GAB1 GC GRB2 HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 ITGB3BP KARS1 KHDRBS1 KIAA0408 KIT KLC2 KLF15 KMT2B L3MBTL3 LAP3 LNX2 LUC7L2 MBIP MECOM MET MICAL1 MTF2 NAB2 NCK1 NEBL NEDD9 ORM1 PACRGL PBX4 PCDHB5 PDGFRB PELO PIK3CA PLAAT4 PLB1 PLEKHF2 PPARA PRKAR1B PSME1 PTK2 QARS1 RB1 RING1 RUSC1 SERF1A SERTAD2 SPATA32 SPMIP6 SRC SSBP4 STAT3 STAT5B TASOR2 TEC TERF2 TNK2 TNNC2 TNNI1 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 YES1 YPEL3 ZBTB18 ZMAT1 ZNF281 ZNF451 ZNF620
Entrez ID		10589	8503
HPRD ID		03796	05831
Ensembl ID		ENSG00000175550	ENSG00000117461
Uniprot IDs		Q14919	B4DXM8 Q8N381 Q92569
PDB IDs		1JFI
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Activity Protein Heterodimerization Activity Transcription Factor TFIID Complex DNA-binding Transcription Factor Binding RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly DNA-templated Transcription Initiation Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-DNA Complex Assembly Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Cellular Response To Stress Regulation Of Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II ATAC Complex Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Autophagosome Assembly Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Nucleic Acid Metabolic Process Transcription Factor TFTC Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein-containing Complex Organization Chromatin Organization Regulation Of Apoptotic Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Metabolic Process Cytoskeletal Anchor Activity Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Remodeling TBP-class Protein Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Receptor Internalization BHLH Transcription Factor Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity ERBB Signaling Pathway Kinase Activity Phosphorylation Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Phosphorylation Ephrin Receptor Binding Positive Regulation Of Phosphate Metabolic Process Ephrin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Binding Insulin-like Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Protein Binding Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cellular Response To Oxygen-containing Compound Response To Peptide Hormone SH2 Domain Binding Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of Programmed Cell Death ATP Binding Positive Regulation Of Cell Population Proliferation Cellular Response To Peptide Hormone Stimulus Response To Platelet-derived Growth Factor Regulation Of Phosphorus Metabolic Process Cell Population Proliferation Insulin Receptor Complex Transferase Activity Positive Regulation Of Cellular Component Organization Receptor Complex Signaling Adaptor Activity Insulin Receptor Substrate Binding Regulation Of Signal Transduction Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway
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