CCT7 and RAP1B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CCT7	RAP1B
Gene Name		chaperonin containing TCP1, subunit 7 (eta)	RAP1B, member of RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Zona Pellucida Receptor Complex Cytoplasm Mitochondrion Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome	Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Identical Protein Binding Unfolded Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC	Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS			White blood cell count ( 20139978)
Protein-Protein Interactions		19 interactors: ANXA1 ANXA7 APP ATP5C1 CDKN1A CEBPE CRMP1 DNM2 EEF1G KAT5 KRAS MED31 NKX3-1 PRPF40A RAP1B RCC1 SSSCA1 SUMO4 TCP1	29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		10574	5908
HPRD ID		06896	01546
Ensembl ID		ENSG00000135624	ENSG00000127314
Uniprot IDs		Q99832	B7ZAY2 P61224
PDB IDs			3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Response To Organic Cyclic Compound Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Response To Radiation Response To Steroid Hormone Regulation Of Cell Cycle Process Response To Lipid Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Mitotic Cell Cycle Arrest Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Epithelium Development Positive Regulation Of Cellular Protein Metabolic Process Response To Ionizing Radiation Regulation Of Protein Kinase Activity Cellular Response To Organic Cyclic Compound Cellular Metabolic Process Response To Glucocorticoid Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Response To X-ray Cellular Response To Lipid Response To Corticosteroid Regulation Of Kinase Activity Hemostasis Regulation Of Myeloid Cell Apoptotic Process Anatomical Structure Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Cell Cycle Regulation Of Cellular Component Organization Androgen Receptor Signaling Pathway Social Behavior Intracellular Receptor Signaling Pathway Positive Regulation Of Kinase Activity Cell Differentiation Positive Regulation Of Protein Modification Process Response To Stress Regulation Of Apoptotic Process Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Response To Hormone Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway	Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization
Tagcloud ?		adequately cct3 cct5 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Difference) ?		adequately cct3 cct5 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Intersection) ?