CCT7 and WBP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCT7	WBP2
Description		chaperonin containing TCP1 subunit 7	WW domain binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Establishment Of Protein Localization To Chromatin Cellular Response To Estrogen Stimulus
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)	Adult body size ( 32376654) Platelet count ( 32888494) Red blood cell count ( 32888494) White matter hyperintensities ( 32358547)
Interacting Genes		26 interacting genes: ANXA1 ANXA7 APP ATP5F1C BTG3 CDKN1A CEBPA CEBPE CRMP1 DNM2 EEF1G KAT5 KRAS LINC01554 MED31 NHLH1 NKX3-1 OGT PRPF40A RAP1B RCC1 SUMO4 TCP1 VHL WBP2 ZNRD2	54 interacting genes: ANAPC1 ANKRD13A ANKRD13D ARCN1 BAG3 CCT7 CLEC4G COPA COPB1 COPB2 COPE COPG1 CUEDC1 DDX17 EEF1B2 EPN2 ESR1 GRPEL1 H4C1 HUWE1 ITCH KRT18 KRT8 KRT9 LGALS8 MAGEA4 MAGI1 MYO6 NEDD4 NEDD4L PAX8 POLH RHBDD3 RNF168 RPS27A RPS3 RUNX1 SDHA SEPTIN3 SMAD5 TDP2 TOLLIP TOM1L2 UBA52 UBC UBE2E3 UBE3A UBQLN1 UIMC1 WWC3 WWP1 WWP2 WWTR1 YAP1
Entrez ID		10574	23558
HPRD ID		06896	06097
Ensembl ID		ENSG00000135624	ENSG00000132471
Uniprot IDs		Q99832	A6NG10 Q969T9
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Binding Response To Steroid Hormone Response To Lipid Regulation Of Cell Cycle Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Binding Intracellular Signal Transduction Protein-containing Complex Binding Negative Regulation Of Gene Expression Regulation Of Programmed Cell Death Positive Regulation Of Cell Activation Regulation Of Gene Expression Response To Hormone Positive Regulation Of Gene Expression Response To Ketone Chromatin DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Developmental Process Phagocytosis Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Cellular Developmental Process Regulation Of Cell Population Proliferation Histone Acetyltransferase Complex Regulation Of Cell Junction Assembly Molecular Function Activator Activity Developmental Process Regulation Of Long-term Neuronal Synaptic Plasticity Phagocytic Cup Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Amyloid Fibril Formation Granulocyte Differentiation Chromatin Positive Regulation Of Mitotic Cell Cycle Response To Glucocorticoid Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	COPI Vesicle Coat COPI-coated Vesicle Membrane Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cytosol Protein Ubiquitination Protein Modification By Small Protein Conjugation COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Polyubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Transport Vesicle Protein Monoubiquitination Nucleoplasm Protein K48-linked Ubiquitination Structural Molecule Activity Membrane Coat Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Proteolysis Cytoplasm Potassium Channel Inhibitor Activity Protein K63-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Nephron Tubule Epithelial Cell Differentiation Extracellular Exosome Catabolic Process Protein Tag Activity Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Ubiquitin Protein Ligase Activity Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Proteasomal Protein Catabolic Process Nuclear Receptor-mediated Signaling Pathway Ubiquitin Binding Protein Catabolic Process Golgi Vesicle Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Histone Ubiquitin Ligase Activity Intracellular Protein Transport Negative Regulation Of Potassium Ion Transmembrane Transport Vesicle-mediated Transport Cytoplasmic Vesicle Cardiac Muscle Tissue Regeneration Intracellular Protein Localization Negative Regulation Of Cation Transmembrane Transport
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