CCT7 and ZNRD2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CCT7	ZNRD2
Description		chaperonin containing TCP1 subunit 7	zinc ribbon domain containing 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Exosome	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Mitotic Cell Cycle Cell Division
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)	Glaucoma (primary open-angle) ( 33627673)
Interacting Genes		26 interacting genes: ANXA1 ANXA7 APP ATP5F1C BTG3 CDKN1A CEBPA CEBPE CRMP1 DNM2 EEF1G KAT5 KRAS LINC01554 MED31 NHLH1 NKX3-1 OGT PRPF40A RAP1B RCC1 SUMO4 TCP1 VHL WBP2 ZNRD2	27 interacting genes: ACTN2 CATSPERT CCDC33 CCNH CCT2 CCT3 CCT5 CCT7 FNDC11 FXR2 IL16 INCA1 MYO15B NME6 NOC4L PIAS2 RNF115 RNF4 SNAPC5 STAT3 SUMO1P1 TRAF3IP3 TRAPPC6A UBC UBE2I VTA1 ZMYM5
Entrez ID		10574	10534
HPRD ID		06896	06921
Ensembl ID		ENSG00000135624	ENSG00000173465
Uniprot IDs		Q99832	G3V1B8 O60232
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	6HCZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Binding Response To Steroid Hormone Response To Lipid Regulation Of Cell Cycle Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Binding Intracellular Signal Transduction Protein-containing Complex Binding Negative Regulation Of Gene Expression Regulation Of Programmed Cell Death Positive Regulation Of Cell Activation Regulation Of Gene Expression Response To Hormone Positive Regulation Of Gene Expression Response To Ketone Chromatin DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Developmental Process Phagocytosis Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Cellular Developmental Process Regulation Of Cell Population Proliferation Histone Acetyltransferase Complex Regulation Of Cell Junction Assembly Molecular Function Activator Activity Developmental Process Regulation Of Long-term Neuronal Synaptic Plasticity Phagocytic Cup Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Amyloid Fibril Formation Granulocyte Differentiation Chromatin Positive Regulation Of Mitotic Cell Cycle Response To Glucocorticoid Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida ATP-dependent Protein Folding Chaperone Sperm-egg Recognition Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Cell-cell Recognition Protein Folding Chaperone Positive Regulation Of Telomere Maintenance Cell Body Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Chromosome Organization PML Body Regulation Of Telomere Maintenance Unfolded Protein Binding Protein Stabilization Regulation Of Chromosome Organization Cell Recognition Zona Pellucida Receptor Complex Protein Sumoylation Regulation Of Protein Localization To Nucleus Protein Tag Activity Regulation Of Protein Stability Protein Folding Transcription Factor Binding SUMO Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Actin Filament Uncapping SUMO Conjugating Enzyme Activity RNA Polymerase II General Transcription Initiation Factor Activity Protein K11-linked Ubiquitination Post-translational Protein Modification Microtubule
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