CCT7 and ANXA1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CCT7	ANXA1
Gene Name		chaperonin containing TCP1, subunit 7 (eta)	annexin A1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Zona Pellucida Receptor Complex Cytoplasm Mitochondrion Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Plasma Membrane Focal Adhesion Cilium Cell Surface Basolateral Plasma Membrane Mitochondrial Membrane Vesicle Sarcolemma Mast Cell Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Identical Protein Binding Unfolded Protein Binding	Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Receptor Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Protein Binding, Bridging Double-stranded DNA-dependent ATPase Activity Annealing Helicase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport	DNA Strand Renaturation Neutrophil Homeostasis Movement Of Cell Or Subcellular Component Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To X-ray Peptide Cross-linking Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Response To Estradiol DNA Duplex Unwinding Positive Regulation Of Neutrophil Apoptotic Process DNA Rewinding Gliogenesis Regulation Of Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Alpha-beta T Cell Differentiation Arachidonic Acid Secretion Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Neutrophil Clearance Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Interleukin-8 Secretion
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formyl peptide receptors bind formyl peptides and many other ligands G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs			Amcinonide Hydrocortisone Dexamethasone
Diseases
GWAS			Schizophrenia, bipolar disorder and depression (combined) ( 20713499)
Protein-Protein Interactions		19 interactors: ANXA1 ANXA7 APP ATP5C1 CDKN1A CEBPE CRMP1 DNM2 EEF1G KAT5 KRAS MED31 NKX3-1 PRPF40A RAP1B RCC1 SSSCA1 SUMO4 TCP1	31 interactors: APBB1 C14orf1 C1orf123 CCT7 COPS6 CSAD DYSF EGFR FAF1 FPR1 GAPDH HMGA1 KLHL23 KMT2B KRT8 LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 XRCC6 YWHAQ
Entrez ID		10574	301
HPRD ID		06896	01060
Ensembl ID		ENSG00000135624	ENSG00000135046
Uniprot IDs		Q99832	P04083 Q5TZZ9
PDB IDs			1AIN 1BO9 1QLS
Enriched GO Terms of Interacting Partners?		Response To Organic Cyclic Compound Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Response To Radiation Response To Steroid Hormone Regulation Of Cell Cycle Process Response To Lipid Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Mitotic Cell Cycle Arrest Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Epithelium Development Positive Regulation Of Cellular Protein Metabolic Process Response To Ionizing Radiation Regulation Of Protein Kinase Activity Cellular Response To Organic Cyclic Compound Cellular Metabolic Process Response To Glucocorticoid Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Response To X-ray Cellular Response To Lipid Response To Corticosteroid Regulation Of Kinase Activity Hemostasis Regulation Of Myeloid Cell Apoptotic Process Anatomical Structure Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Cell Cycle Regulation Of Cellular Component Organization Androgen Receptor Signaling Pathway Social Behavior Intracellular Receptor Signaling Pathway Positive Regulation Of Kinase Activity Cell Differentiation Positive Regulation Of Protein Modification Process Response To Stress Regulation Of Apoptotic Process Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Response To Hormone Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway	Negative Regulation Of Biosynthetic Process Viral Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Caveolin-mediated Endocytosis Establishment Of Integrated Proviral Latency Positive Regulation Of Transferase Activity Establishment Of Viral Latency Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Growth Factor Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Peptidyl-amino Acid Modification Organ Development Magnesium Ion Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Programmed Cell Death Organelle Organization Catabolic Process Cell Death Death Positive Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Response To Stimulus Regulation Of Gene Expression Peptidyl-lysine Modification Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Brain Development Reproductive Structure Development Ubiquitin-dependent Protein Catabolic Process Reproductive System Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Tagcloud ?		adequately cct3 cct5 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth	aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		adequately cct3 cct5 crc csnk2a2 discover discriminative gna12 hypotheses ifitm1 igfbp3 integrating legacy merely merit mutual outlines pdgfrb plk1 proteomics proxy pruned resultant scheme scoring sized subnetwork subnetworks wealth	aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?