NGFRAP1 and NTRK3

Number of citations of the paper that reports this interaction (PMID 10764727)
25

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NGFRAP1	NTRK3
Gene Name		nerve growth factor receptor (TNFRSF16) associated protein 1	neurotrophic tyrosine kinase, receptor, type 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Metal Ion Binding	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding Ephrin Receptor Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organismal Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Apoptotic Signaling Pathway	Activation Of MAPK Activity Neuron Migration Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Transcription Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Response To Ethanol Protein Autophosphorylation Neuron Fate Specification Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Negative Regulation Of Cell Death Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling NADE modulates death signalling
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Gaucher disease severity ( 22388998)
Protein-Protein Interactions		28 interactors: AIMP2 CACYBP CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 FSD2 GOLGA8EP GOLGA8F MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 SIVA1 SMPD1 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSC1 USHBP1 VTA1 YWHAE	20 interactors: APP DOK5 DYNLL1 FRS2 HTR2A IRAK1 IRAK3 JUN KIDINS220 MAPK1 MAPK3 NGFR NGFRAP1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SQSTM1
Entrez ID		27018	4916
HPRD ID		02291	01870
Ensembl ID		ENSG00000166681	ENSG00000140538
Uniprot IDs		Q00994	B7Z7U4 H0YND1 Q16288 Q96CY4
PDB IDs		1SA6	1WWC 3V5Q
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process NIK/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Stimulus Regulation Of MAPK Cascade Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity	Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Signaling Activation Of Protein Kinase Activity Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Transferase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Stimulus Activation Of MAPK Activity Positive Regulation Of Phosphorylation Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Insulin Receptor Signaling Pathway Activation Of MAPKK Activity
Tagcloud ?		abcf2 adprtl1 amy2b arhgap4 atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		abcf2 adprtl1 amy2b arhgap4 atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?