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NGFRAP1 and SMPD1
Number of citations of the paper that reports this interaction (PMID
11238738
)
7
Data Source:
HPRD
(in vivo)
NGFRAP1
SMPD1
Gene Name
nerve growth factor receptor (TNFRSF16) associated protein 1
sphingomyelin phosphodiesterase 1, acid lysosomal
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Extracellular Space
Lysosome
Endosome
Plasma Membrane
Lamellar Body
Lysosomal Lumen
Extracellular Vesicular Exosome
Molecular Function
Death Receptor Binding
Protein Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Metal Ion Binding
Sphingomyelin Phosphodiesterase Activity
Protein Binding
Hydrolase Activity, Acting On Glycosyl Bonds
Biological Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Multicellular Organismal Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neurotrophin TRK Receptor Signaling Pathway
Apoptotic Signaling Pathway
Sphingolipid Metabolic Process
Sphingomyelin Metabolic Process
Sphingomyelin Catabolic Process
Glycosphingolipid Metabolic Process
Signal Transduction
Nervous System Development
Termination Of Signal Transduction
Positive Regulation Of Protein Dephosphorylation
Response To Cocaine
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Small Molecule Metabolic Process
Ceramide Biosynthetic Process
Pathways
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
NADE modulates death signalling
Sphingolipid metabolism
Metabolism of lipids and lipoproteins
Glycosphingolipid metabolism
Drugs
Desipramine
Diseases
GWAS
Protein-Protein Interactions
28 interactors:
AIMP2
CACYBP
CCDC116
CCDC85B
CTNNBL1
DIABLO
EMILIN1
FSD2
GOLGA8EP
GOLGA8F
MIF
MNAT1
NECAB2
NGFR
NTRK3
PTPN13
SIVA1
SMPD1
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
TSC1
USHBP1
VTA1
YWHAE
6 interactors:
ANXA4
ANXA7
ASAH1
DUSP23
NGFRAP1
NR1H2
Entrez ID
27018
6609
HPRD ID
02291
06353
Ensembl ID
ENSG00000166681
ENSG00000166311
Uniprot IDs
Q00994
G3XAB5
P17405
Q59EN6
PDB IDs
1SA6
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Death
Regulation Of Apoptotic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Protein Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Metabolic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Catalytic Activity
Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
NIK/NF-kappaB Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of MAP Kinase Activity
Regulation Of Cellular Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorylation
Apoptotic Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Immune Response
Cellular Response To Stimulus
Regulation Of MAPK Cascade
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Cell Death
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Regulation Of Cell Proliferation
Positive Regulation Of Apoptotic Signaling Pathway
Response To Organic Substance
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Secretion Of Lysosomal Enzymes
Positive Regulation Of Pancreatic Juice Secretion
Positive Regulation Of High-density Lipoprotein Particle Assembly
Regulation Of High-density Lipoprotein Particle Assembly
Negative Regulation Of Interleukin-8 Secretion
Negative Regulation Of Pinocytosis
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Response To Organic Substance
Negative Regulation Of Cholesterol Storage
Positive Regulation Of Digestive System Process
Cellular Water Homeostasis
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Lipoprotein Lipase Activity
Positive Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Interleukin-8 Secretion
Regulation Of Cholesterol Homeostasis
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Regulation Of Protein Secretion
Negative Regulation Of Transport
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Transport
Negative Regulation Of Lipid Storage
Regulation Of Triglyceride Biosynthetic Process
Regulation Of Cholesterol Efflux
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Response To Interferon-gamma
Negative Regulation Of Lipid Transport
Retinoic Acid Receptor Signaling Pathway
Epithelial Cell Differentiation
Positive Regulation Of Lipid Storage
Cell Volume Homeostasis
Positive Regulation Of Fatty Acid Metabolic Process
Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Triglyceride Metabolic Process
Regulation Of Cholesterol Transport
Negative Regulation Of Cytokine Secretion
Response To Salt Stress
Regulation Of Protein Transport
Negative Regulation Of Innate Immune Response
Negative Regulation Of Cytokine-mediated Signaling Pathway
Tagcloud
?
abcf2
adprtl1
amy2b
arhgap4
atp6ap1
axin1
casp4
cox1
cox7b
ctsl
etv4
lgals3bp
mgc35136
mgc5528
mt2a
mt3
p53scv
ppia
prdx2
psap
scgb2a2
smoc2
sptan1
sra1
tax1bp1
tpd52l1
tra1
trf4
tuba4
Tagcloud (Difference)
?
abcf2
adprtl1
amy2b
arhgap4
atp6ap1
axin1
casp4
cox1
cox7b
ctsl
etv4
lgals3bp
mgc35136
mgc5528
mt2a
mt3
p53scv
ppia
prdx2
psap
scgb2a2
smoc2
sptan1
sra1
tax1bp1
tpd52l1
tra1
trf4
tuba4
Tagcloud (Intersection)
?