BEX3 and AIMP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BEX3	AIMP2
Description		brain expressed X-linked 3	aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity	Protein Binding Protein-macromolecule Adaptor Activity Molecular Adaptor Activity
	Biological Process	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Ubiquitination	Translation Apoptotic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Type II Pneumocyte Differentiation Protein-containing Complex Assembly
Pathways		NADE modulates death signalling	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		43 interacting genes: AIMP2 BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO DSCR9 EMILIN1 ENKD1 FSD2 FTCD GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417	103 interacting genes: AIMP1 APP BCAS2 BEX3 BLOC1S4 BRME1 BYSL C1orf216 CBY2 CEBPA CEP126 CHD3 DARS1 DARS2 DEAF1 DISC1 DRC12 DSN1 EPRS1 EPS8 EXOC8 FGB FHL3 FILNC1 FUBP1 GYS1 ICE1 KARS1 KDR KLC2 KRT31 KRT33B KRT34 KRT36 LMO2 LMO3 LNX1 LUC7L2 MATR3 MCF2L MIR106A MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR15A MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR34A MIR34B MIR34C MIR429 MIR451A MIR7-1 MIR7-2 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I MIS18A NDEL1 NECAB2 NTAQ1 PFDN6 PLEKHF2 PPP2R1A PRKAA2 PRKN PSME1 RABEP1 SBK3 SLU7 SMURF2 SPATA18 TANK TCP11 TERF2IP TEX12 TFIP11 TRAF2 TRMT2A ZC3H12A ZGPAT
Entrez ID		27018	7965
HPRD ID		02291	02915
Ensembl ID		ENSG00000166681	ENSG00000106305
Uniprot IDs		Q00994	A8MU58 Q13155
PDB IDs			4DPG 4YCU 4YCW 5A1N 5A34 5A5H 5Y6L 6ILD 6IY6 6JPV 6K39 8J9S 9DPL
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Programmed Cell Death CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction A2A Adenosine Receptor Binding DNA Replication-dependent Chromatin Disassembly Regulation Of MAPK Cascade Neurotrophin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Process Identical Protein Binding Cell Death Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Macrophage Migration S100 Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Cytoplasm Zinc Ion Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Histone H3K4me3 Reader Activity Regulation Of Macromolecule Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Cytokine Production Negative Regulation Of Signal Transduction Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Sprouting Angiogenesis Extracellular Space Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility
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