BEX3 and S100Z

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BEX3	S100Z
Description		brain expressed X-linked 3	S100 calcium binding protein Z
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Ubiquitination
Pathways		NADE modulates death signalling
Drugs
Diseases
GWAS			Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		43 interacting genes: AIMP2 BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO DSCR9 EMILIN1 ENKD1 FSD2 FTCD GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417	10 interacting genes: BEX3 OIP5 RASSF2 RBM48 S100A1 S100A10 S100A3 S100B S100P SNAPC5
Entrez ID		27018	170591
HPRD ID		02291	15291
Ensembl ID		ENSG00000166681	ENSG00000171643
Uniprot IDs		Q00994	Q8WXG8
PDB IDs			5HYD
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Programmed Cell Death CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction A2A Adenosine Receptor Binding DNA Replication-dependent Chromatin Disassembly Regulation Of MAPK Cascade Neurotrophin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Process Identical Protein Binding Cell Death Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Macrophage Migration S100 Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Cytoplasm Zinc Ion Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Histone H3K4me3 Reader Activity Regulation Of Macromolecule Metabolic Process	Calcium-dependent Protein Binding Calcium Ion Binding S100 Protein Binding Transition Metal Ion Binding Protein Homodimerization Activity
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