BEX3 and ING5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BEX3	ING5
Description		brain expressed X-linked 3	inhibitor of growth family member 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Ubiquitination	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Organization Regulation Of DNA-templated Transcription Protein Acetylation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Growth Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Developmental Process Regulation Of Cell Cycle Apoptotic Signaling Pathway DNA Replication-dependent Chromatin Disassembly Regulation Of Hemopoiesis Regulation Of DNA Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		NADE modulates death signalling	HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS			Asthma ( 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Platelet distribution width ( 32888494)
Interacting Genes		43 interacting genes: AIMP2 BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO DSCR9 EMILIN1 ENKD1 FSD2 FTCD GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417	45 interacting genes: APC APLP1 ARFIP2 BARD1 BEX3 C3orf62 CBY2 CCDC33 CCHCR1 CDCA7L CDK2 CDKN1A CEP126 CEP44 DEUP1 EP300 FAM118B GCSH GGA1 GRIPAP1 HAP1 HGS HTT ICA1 IKZF3 KRT40 KRTAP10-7 KXD1 MBIP MCM6 MEST NAV2 ODF2 PCM1 PRMT5 RCOR3 SMARCE1 SUOX TADA3 TAF1D THAP6 TP53 TRIML2 VIM WASF1
Entrez ID		27018	84289
HPRD ID		02291	16348
Ensembl ID		ENSG00000166681	ENSG00000168395
Uniprot IDs		Q00994	A0A1B0GW41 Q8WYH8
PDB IDs			3C6W 5ME8 5MTO
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Programmed Cell Death CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction A2A Adenosine Receptor Binding DNA Replication-dependent Chromatin Disassembly Regulation Of MAPK Cascade Neurotrophin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Process Identical Protein Binding Cell Death Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Macrophage Migration S100 Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Cytoplasm Zinc Ion Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Histone H3K4me3 Reader Activity Regulation Of Macromolecule Metabolic Process	Identical Protein Binding Centriole Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Protein Binding Cytosol Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Domain Specific Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Centriole Replication P53 Binding Membrane Curvature Sensor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Organization Centriole Assembly Organelle Transport Along Microtubule Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Transport Along Microtubule Regulation Of Cell Cycle G1/S Phase Transition Stress-induced Premature Senescence Protein-containing Complex Cytoskeleton-dependent Intracellular Transport Intracellular Transport Regulation Of Organelle Organization Microtubule-based Process Negative Regulation Of Mitotic Cell Cycle Nuclear Receptor Binding Neurogenesis Regulation Of Mitotic Cell Cycle Phase Transition Centrosome Regulation Of DNA Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Replication Microtubule-based Transport Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Cyclin-dependent Protein Kinase Activity Nucleoplasm Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Centriole-centriole Cohesion Regulation Of Intracellular Protein Transport ATAC Complex Cellular Senescence Regulation Of Intracellular Transport Small GTPase-mediated Signal Transduction Establishment Of Organelle Localization Replicative Senescence
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