BEX3 and PTPN13

Number of citations of the paper that reports this interaction (PubMedID 10544233)
0

Data Source:
HPRD (in vitro, in vivo)

		BEX3	PTPN13
Description		brain expressed X-linked 3	protein tyrosine phosphatase non-receptor type 13
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Cell Projection Cell Body Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Ubiquitination	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Toxic Substance Negative Regulation Of Excitatory Synapse Assembly
Pathways		NADE modulates death signalling	Synthesis of PIPs at the plasma membrane Interleukin-37 signaling RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Tinnitus ( 33742053) Word spelling ( 30741946)
Interacting Genes		43 interacting genes: AIMP2 BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO DSCR9 EMILIN1 ENKD1 FSD2 FTCD GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417	26 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 DSCAM EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 VANGL2 YWHAZ
Entrez ID		27018	5783
HPRD ID		02291	02602
Ensembl ID		ENSG00000166681	ENSG00000163629
Uniprot IDs		Q00994	Q12923
PDB IDs			1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ 7QCX 7QCY 7XTY
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Programmed Cell Death CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction A2A Adenosine Receptor Binding DNA Replication-dependent Chromatin Disassembly Regulation Of MAPK Cascade Neurotrophin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Process Identical Protein Binding Cell Death Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Macrophage Migration S100 Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Cytoplasm Zinc Ion Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Histone H3K4me3 Reader Activity Regulation Of Macromolecule Metabolic Process	Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Apoptotic Signaling Pathway Protein Phosphatase Binding Glutamatergic Synapse Neuron Projection Guidance Axon Guidance Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction CD95 Death-inducing Signaling Complex Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Cell Junction Assembly Positive Regulation Of Cell Population Proliferation Tube Formation Death-inducing Signaling Complex Cell Junction Organization Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Assembly Regulation Of Intracellular Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Population Proliferation Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Cellular Developmental Process Cell-cell Junction Organization Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Beta-catenin Destruction Complex Positive Regulation Of Apoptotic Process Lateral Plasma Membrane Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Cell Projection Organization Rho Protein Signal Transduction Wnt Signalosome Adherens Junction Nervous System Development Lamellipodium
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