TCL1B and LSM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCL1B	LSM5
Description		TCL1 family AKT coactivator B	LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity	RNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Intracellular Signal Transduction	MRNA Splicing, Via Spliceosome MRNA Processing MRNA Catabolic Process RNA Splicing Response To Bacterium
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Body mass index ( 26426971) Extremely high intelligence ( 29520040) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Morning person ( 30696823) Palmitic acid (16:0) levels ( 23362303) Smooth-surface caries ( 24556642)
Interacting Genes		17 interacting genes: AKT1 AKT2 APP BAG4 DRC8 GLRX3 LSM1 LSM5 LSM7 MARK1 MEIS3 MKRN3 PLEKHA3 PNMA1 SNRPG TNPO2 ZNF330	23 interacting genes: CEBPA CPSF7 DDIT4L EXOSC5 HNRNPD LARP4 LSM1 LSM2 LSM3 LSM6 LSM7 LSM8 PLK3 PRPF38B PRRC2B QKI RBFOX2 SMN1 SNRPE SNRPF SPMIP10 TBPL1 TCL1B
Entrez ID		9623	23658
HPRD ID		04795	06285
Ensembl ID		ENSG00000213231	ENSG00000106355
Uniprot IDs		O95988	A0A090N8Y5 Q9Y4Y9
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Lsm1-7-Pat1 Complex Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane U4/U6 X U5 Tri-snRNP Complex Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Ribonucleoprotein Complex Spliceosomal Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex U6 SnRNP RNA Splicing, Via Transesterification Reactions Negative Regulation Of PERK-mediated Unfolded Protein Response Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fibroblast Migration U2-type Prespliceosome Nucleus Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Polysaccharide Biosynthetic Process MRNA Catabolic Process Molecular Function Activator Activity U12-type Spliceosomal Complex Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Postsynapse Organization RNA Binding RNA Splicing Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Transport Regulation Of Fatty Acid Oxidation Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Protein Localization To Plasma Membrane Regulation Of Fibroblast Migration Response To Nerve Growth Factor Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Glycogen Metabolic Process Cell Cortex Regulation Of TRNA Methylation	MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing RNA Metabolic Process RNA Binding RNA Splicing, Via Transesterification Reactions U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP Nucleic Acid Metabolic Process Lsm1-7-Pat1 Complex Precatalytic Spliceosome Spliceosomal Complex MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Macromolecule Metabolic Process Catalytic Step 2 Spliceosome RNA Catabolic Process Spliceosomal SnRNP Assembly U6 SnRNA Binding MRNA Catabolic Process MRNA Binding Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex U12-type Spliceosomal Complex Nucleobase-containing Compound Catabolic Process P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation Nucleus U4 SnRNP Nucleoplasm Methylosome Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process U1 SnRNP U5 SnRNP Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Gene Expression U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Nucleic Acid Binding
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