HEXD and EEF1D

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HEXD	EEF1D
Description		hexosaminidase D	eukaryotic translation elongation factor 1 delta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicle	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Hexosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Heat Shock Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding
	Biological Process	Carbohydrate Metabolic Process	Cytoplasmic Translational Elongation Translation Translational Elongation Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Ionizing Radiation
Pathways			Eukaryotic Translation Elongation
Drugs
Diseases
GWAS			Schizophrenia ( 31268507)
Interacting Genes		9 interacting genes: ADPRS C7orf25 EEF1D GDPD2 GLRX3 PRKN PSD RILPL2 TUBB3	45 interacting genes: ALX1 APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CEBPA CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 FILNC1 FKBP6 FOS FRA10AC1 GARS1 HEXD KARS1 KTN1 LINC01232 MAP1B NR2F1 POT1 PRKCA RELA RNF20 RNF40 RPS6KA1 SIAH1 SIAH2 SLC26A4-AS1 SNCA TERF1 TINF2 TPT1 UBE2A USP40 USP7 VARS1
Entrez ID		284004	1936
HPRD ID		08677	00560
Ensembl ID		ENSG00000169660	ENSG00000104529
Uniprot IDs		Q8WVB3	B2RAR6 P29692
PDB IDs			2MVM 2MVN 2N51 5JPO
Enriched GO Terms of Interacting Partners?		Heat Shock Protein Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of Necroptotic Process Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Netrin Receptor Binding Glycerophosphoinositol Inositolphosphodiesterase Activity Poly(ADP-ribose) Glycohydrolase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Protein Transport From Ciliary Membrane To Plasma Membrane Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Glycerophosphodiester Phosphodiesterase Activity O-acetyl-ADP-ribose Deacetylase Activity Cytoplasmic Translational Elongation Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Cell Projection Regulation Of Synaptic Vesicle Transport Dorsal Root Ganglion Development Response To Superoxide Protein De-ADP-ribosylation Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion	Protein Metabolic Process Shelterin Complex HULC Complex Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Amyloid Fibril Formation Negative Regulation Of Biosynthetic Process Nuclear Telomere Cap Complex Positive Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Telomere Capping TRNA Aminoacylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nucleic Acid Metabolic Process Diadenosine Tetraphosphate Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Chromatin Binding Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation Telomere Assembly Chromatin Organization Regulation Of Protein Catabolic Process Telomeric DNA Binding Nucleus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Interleukin-1 Regulation Of Synapse Assembly Cytosol Negative Regulation Of DNA Biosynthetic Process Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Copper Ion Response To Peptide Regulation Of Establishment Of Protein Localization To Telomere DNA Metabolic Process DNA-binding Transcription Factor Binding Response To Xenobiotic Stimulus Nucleoplasm Regulation Of Primary Metabolic Process Ankyrin Repeat Binding
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