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HEXDC and TUBB3
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
HEXDC
TUBB3
Gene Name
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
tubulin, beta 3 class III
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Nucleus
Cytoplasm
Microtubule
Axon
Dendrite
Neuronal Cell Body
Extracellular Vesicular Exosome
Cell Periphery
Molecular Function
Beta-N-acetylhexosaminidase Activity
GTPase Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Peptide Binding
Biological Process
Carbohydrate Metabolic Process
Protein Folding
Microtubule-based Process
Mitotic Nuclear Division
Axon Guidance
Cellular Protein Metabolic Process
'de Novo' Posttranslational Protein Folding
Protein Polymerization
Transmembrane Transport
Pathways
Transport of connexons to the plasma membrane
Mitotic Prometaphase
Organelle biogenesis and maintenance
Axon guidance
Hedgehog 'off' state
Separation of Sister Chromatids
Translocation of GLUT4 to the plasma membrane
G2/M Transition
L1CAM interactions
Mitotic Anaphase
Recycling pathway of L1
Recruitment of NuMA to mitotic centrosomes
Formation of tubulin folding intermediates by CCT/TriC
Intraflagellar transport
M Phase
Prefoldin mediated transfer of substrate to CCT/TriC
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Post-chaperonin tubulin folding pathway
Gap junction trafficking and regulation
MHC class II antigen presentation
Recruitment of mitotic centrosome proteins and complexes
Orphan transporters
Protein folding
Gap junction assembly
Gap junction trafficking
Kinesins
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Assembly of the primary cilium
Factors involved in megakaryocyte development and platelet production
Cell Cycle, Mitotic
Resolution of Sister Chromatid Cohesion
Chaperonin-mediated protein folding
Signaling by Hedgehog
Centrosome maturation
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Epothilone D
Epothilone B
Ixabepilone
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
ADPRHL2
C7orf25
EEF1D
GDPD2
GLRX3
PARK2
PSD
RILPL2
TUBB3
27 interactors:
ANXA7
ARHGEF7
CAMSAP3
CDKN1A
DDX39B
EEF1G
GABARAP
GZMK
HEXDC
INSM1
KHDRBS1
LAPTM4A
LIG1
MRPL28
MTCL1
PHIP
PLK1
RCC1
RILPL2
ROBO1
SEL1L3
SMN1
SPTSSA
TERF1
TF
TK1
TPTE
Entrez ID
284004
10381
HPRD ID
08677
04044
Ensembl ID
ENSG00000169660
ENSG00000258947
Uniprot IDs
Q8WVB3
A8K854
Q13509
Q53G92
PDB IDs
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Mitochondrial Fusion
Positive Regulation Of Protein Linear Polyubiquitination
Dopamine Uptake Involved In Synaptic Transmission
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cellular Response To Dopamine
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cellular Response To Manganese Ion
Protein K27-linked Ubiquitination
Protein K29-linked Ubiquitination
Negative Regulation Of Mitochondrial Fusion
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitochondrial Fusion
Negative Regulation Of Glucokinase Activity
Neuron Cellular Homeostasis
Positive Regulation Of Oxidative Stress-induced Cell Death
Protein K6-linked Ubiquitination
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Mitochondrial Fission
Regulation Of Mitochondrion Degradation
Negative Regulation Of Cardiac Muscle Hypertrophy
Dopamine Transport
Negative Regulation Of Muscle Hypertrophy
Aggresome Assembly
Regulation Of Mitochondrial Fission
Neurotransmitter Uptake
Norepinephrine Metabolic Process
Negative Regulation Of Actin Filament Bundle Assembly
Synaptic Transmission, Dopaminergic
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Zinc Ion Homeostasis
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Response To Manganese Ion
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Cellular Response To Ammonium Ion
Cellular Response To Superoxide
Regulation Of Dopamine Secretion
Response To Oxidative Stress
Cellular Response To Toxic Substance
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Monoamine Transport
Mitochondrial Fission
Cellular Response To Catecholamine Stimulus
Negative Regulation Of Oxidative Stress-induced Cell Death
Response To Superoxide
Startle Response
Regulation Of Cell Cycle Process
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Mitotic Cell Cycle Phase Transition
G2/M Transition Of Mitotic Cell Cycle
Cell Cycle Phase Transition
Regulation Of Mitotic Nuclear Division
Positive Regulation Of Cell Cycle
Positive Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Negative Regulation Of Cell Cycle
Mitotic Cell Cycle
Positive Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Cell Division
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Division
Cell Cycle
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Telomere Maintenance Via Telomere Lengthening
Mitotic Spindle Assembly Checkpoint
Cell Cycle Process
Mitotic Cell Cycle Process
Mitotic Cell Cycle Checkpoint
Spindle Assembly Checkpoint
Mitotic Spindle Checkpoint
Response To Toxic Substance
Negative Regulation Of Chromosome Segregation
Cell Division
Cytoskeleton Organization
Microtubule Bundle Formation
Positive Regulation Of Microtubule Motor Activity
Fetal Process Involved In Parturition
Columnar/cuboidal Epithelial Cell Development
Regulation Of DNA Biosynthetic Process
Microtubule-based Process
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Regulation Of Mitotic Metaphase/anaphase Transition
Epithelial Cell Development
Regulation Of Cell Morphogenesis
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Cell Cycle Checkpoint
Spliceosomal Complex Assembly
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud
?
actb
assessments
bestkeeper
brca1
colon
ercc1
esophageal
gapdh
gastrointestinal
genorm
gusb
normalized
normfinder
optimal
personalized
qrt
ranking
rectal
reference
represented
rplpo
rrm1
separately
stmn1
taqman
tfrc
top2a
tyms
vegfr2
Tagcloud (Difference)
?
actb
assessments
bestkeeper
brca1
colon
ercc1
esophageal
gapdh
gastrointestinal
genorm
gusb
normalized
normfinder
optimal
personalized
qrt
ranking
rectal
reference
represented
rplpo
rrm1
separately
stmn1
taqman
tfrc
top2a
tyms
vegfr2
Tagcloud (Intersection)
?