HEXD and RILPL2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HEXD	RILPL2
Description		hexosaminidase D	Rab interacting lysosomal protein like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicle	Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Ciliary Basal Body Cell Projection
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Hexosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	Protein Binding Small GTPase Binding Identical Protein Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Carbohydrate Metabolic Process	Epithelial Cell Morphogenesis Protein Transport Cilium Assembly Protein Transport From Ciliary Membrane To Plasma Membrane
Pathways
Drugs
Diseases
GWAS			A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Educational attainment ( 25201988) Height ( 28552196) High density lipoprotein cholesterol levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 27863252) Schizophrenia ( 25056061 29483656 23974872) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: ADPRS C7orf25 EEF1D GDPD2 GLRX3 PRKN PSD RILPL2 TUBB3	2 interacting genes: HEXD TUBB3
Entrez ID		284004	196383
HPRD ID		08677	10084
Ensembl ID		ENSG00000169660	ENSG00000150977
Uniprot IDs		Q8WVB3	Q969X0
PDB IDs			6RIR 6SQ2 7LWB
Enriched GO Terms of Interacting Partners?		Heat Shock Protein Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of Necroptotic Process Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Netrin Receptor Binding Glycerophosphoinositol Inositolphosphodiesterase Activity Poly(ADP-ribose) Glycohydrolase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Protein Transport From Ciliary Membrane To Plasma Membrane Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Glycerophosphodiester Phosphodiesterase Activity O-acetyl-ADP-ribose Deacetylase Activity Cytoplasmic Translational Elongation Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Cell Projection Regulation Of Synaptic Vesicle Transport Dorsal Root Ganglion Development Response To Superoxide Protein De-ADP-ribosylation Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion	Netrin Receptor Binding Dorsal Root Ganglion Development Beta-N-acetylhexosaminidase Activity Hexosaminidase Activity Microtubule Netrin-activated Signaling Pathway Ganglion Development Minus-end-directed Microtubule Motor Activity Axonemal Dynein Complex Peptide Binding Microtubule-based Process 9+2 Motile Cilium Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Dynein Complex Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Microtubule Motor Activity
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