VAV3 and PLCG1

Number of citations of the paper that reports this interaction (PMID 11094073)
32

Data Source:
HPRD (in vivo, in vitro)

		VAV3	PLCG1
Gene Name		vav 3 guanine nucleotide exchange factor	phospholipase C, gamma 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Extracellular Vesicular Exosome	Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Lamellipodium Cell Projection
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Receptor Signaling Protein Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Glutamate Receptor Binding
	Biological Process	Angiogenesis Vesicle Fusion Cellular Response To DNA Damage Stimulus Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Signal Transduction Lamellipodium Assembly Platelet Activation Neutrophil Chemotaxis Positive Regulation Of B Cell Proliferation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Activation Of MAPKK Activity In Utero Embryonic Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Viral Process Cell Migration Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Blood Vessel Endothelial Cell Migration Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by GPCR Axon guidance FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Synthesis of IP3 and IP4 in the cytosol Signaling by FGFR1 mutants Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Inositol phosphate metabolism Antiviral mechanism by IFN-stimulated genes EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR TCR signaling Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Generation of second messenger molecules ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PECAM1 interactions Cell surface interactions at the vascular wall Role of second messengers in netrin-1 signaling PLC-gamma1 signalling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Hypothyroidism ( 22493691)
Protein-Protein Interactions		17 interactors: EGFR ERBB2 ERBB3 ESR1 GRB2 IGF1R INSR LCP2 PIK3R1 PLCG1 RAC1 RHOA RHOG ROS1 SH3BP2 SHC1 ZYX	106 interactors: ABL1 AGAP2 AGTR1 AKT1 ALK ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GNB2L1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PTK2 PTPN11 PTPRJ RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70
Entrez ID		10451	5335
HPRD ID		05706	01398
Ensembl ID		ENSG00000134215	ENSG00000124181
Uniprot IDs		Q9UKW4	P19174 Q4LE43 Q9UFY1
PDB IDs		2D86	1HSQ 2HSP 4EY0 4FBN
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Wound Healing Regulation Of Intracellular Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Wounding Signal Transduction Cellular Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Platelet Activation Response To Fibroblast Growth Factor Regulation Of Phosphorylation Blood Coagulation Intracellular Signal Transduction Hemostasis Response To Organic Substance Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Axonogenesis Phosphatidylinositol 3-kinase Signaling Axon Development Regulation Of Immune Response Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Immune Response Regulation Of MAPK Cascade Axon Guidance Neuron Projection Morphogenesis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Locomotion Protein Autophosphorylation Fc Receptor Signaling Pathway Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Innate Immune Response Regulation Of Signal Transduction Response To Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Migration Cell Motility Response To Organic Substance Defense Response Regulation Of Immune Response Immune Response Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-amino Acid Modification Cellular Response To Growth Factor Stimulus Immune System Process Response To Wounding Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Substance Developmental Process Response To External Stimulus Wound Healing Protein Phosphorylation Regulation Of Catalytic Activity Phosphatidylinositol-mediated Signaling Cell Differentiation Regulation Of Cell Proliferation Peptidyl-tyrosine Autophosphorylation
Tagcloud ?		anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vinorelbine	13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2
Tagcloud (Difference) ?		anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vinorelbine	13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2
Tagcloud (Intersection) ?