VAV3

Description		vav guanine nucleotide exchange factor 3
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Angiogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle Fusion DNA Damage Response Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Cell Projection Assembly Lamellipodium Assembly Platelet Activation Neutrophil Chemotaxis Positive Regulation Of B Cell Proliferation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Adhesion B Cell Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Asthma and hay fever ( 24388013) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Differentiated thyroid cancer ( 28703219) Eosinophil percentage of white cells ( 32888494) Facial wrinkles (principal components analysis) ( 33959940) Hashimoto thyroiditis versus Graves' disease ( 25429627) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965 30367059 22493691) IgA nephropathy ( 25305756) Medication use (thyroid preparations) ( 31015401) Night sleep phenotypes ( 27126917) Papillary thyroid cancer ( 28703219) Plasma thyroid-stimulating hormone levels ( 24722205) Refractive error ( 32231278) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		25 interacting genes: AR CBLB EGFR ERBB2 ERBB3 ERBB4 ESR1 GAB1 GRB2 IGF1R INSR KIT LCP2 MET PIK3R1 PLCG1 RAC1 RHOA RHOG RINT1 ROS1 SH3BP2 SHC1 ZRANB1 ZYX
Entrez ID		10451
HPRD ID		05706
Ensembl ID		ENSG00000134215
Uniprot IDs		Q9UKW4
PDB IDs		2D86
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Tyrosine Kinase Activity Intracellular Signal Transduction Receptor Complex Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Neurotrophin TRKA Receptor Binding Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Insulin-like Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Insulin Receptor Substrate Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphate Metabolic Process Intracellular Signaling Cassette Regulation Of Developmental Process Protein Kinase Activity Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling ErbB-3 Class Receptor Binding Insulin Binding Positive Regulation Of Metabolic Process Plasma Membrane Positive Regulation Of Protein Phosphorylation ERBB2 Signaling Pathway Basal Plasma Membrane Positive Regulation Of Protein Modification Process Regulation Of Cell Migration Positive Regulation Of Phosphorylation Regulation Of Cell Motility
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