VAV3 and RHOA

Number of citations of the paper that reports this interaction (PMID 10523675)
61

Data Source:
HPRD (in vitro)

		VAV3	RHOA
Gene Name		vav 3 guanine nucleotide exchange factor	ras homolog family member A
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Extracellular Vesicular Exosome	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding	GTPase Activity Protein Binding GTP Binding Myosin Binding
	Biological Process	Angiogenesis Vesicle Fusion Cellular Response To DNA Damage Stimulus Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Signal Transduction Lamellipodium Assembly Platelet Activation Neutrophil Chemotaxis Positive Regulation Of B Cell Proliferation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Transforming Growth Factor Beta Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Viral Process Substantia Nigra Development Actin Cytoskeleton Organization Platelet Activation Regulation Of Cell Migration Positive Regulation Of Cytokinesis Regulation Of Osteoblast Proliferation Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Positive Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Trabecula Morphogenesis Mitotic Spindle Assembly Skeletal Muscle Satellite Cell Migration
Pathways		Signaling by GPCR Axon guidance FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation	Loss of Function of TGFBR2 in Cancer Signaling by GPCR Axon guidance Axonal growth stimulation SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Rho GTPase cycle EPHA-mediated growth cone collapse Axonal growth inhibition (RHOA activation) PI3K/AKT activation G beta:gamma signalling through PI3Kgamma EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse TGFBR2 MSI Frameshift Mutants in Cancer Signalling by NGF TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer p75NTR regulates axonogenesis G-protein beta:gamma signalling Loss of Function of SMAD2/3 in Cancer Semaphorin interactions TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer p75 NTR receptor-mediated signalling TGFBR1 KD Mutants in Cancer NGF signalling via TRKA from the plasma membrane Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling GPCR downstream signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF Signaling by Rho GTPases GPVI-mediated activation cascade Platelet activation, signaling and aggregation PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer
Drugs			Guanosine-5\'-Diphosphate
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Hypothyroidism ( 22493691)
Protein-Protein Interactions		17 interactors: EGFR ERBB2 ERBB3 ESR1 GRB2 IGF1R INSR LCP2 PIK3R1 PLCG1 RAC1 RHOA RHOG ROS1 SH3BP2 SHC1 ZYX	90 interactors: AKAP13 ARHGAP1 ARHGAP10 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 BCR BIRC2 CAV1 CIT CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DOCK7 DVL2 FAM65B FLNA GMIP GNA12 GNB2L1 HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 MCF2 MCF2L MPRIP NET1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PPP1R12A PRKACA PRKCA PRKCZ RABAC1 RAP1GDS1 RASGRF1 RHPN1 RHPN2 RIPK4 ROCK1 RPN2 RTKN SH3BP1 SMAD2 SMURF1 SMURF2 SPRED2 SRGAP1 TEC TGFBR1 TGM2 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3
Entrez ID		10451	387
HPRD ID		05706	01323
Ensembl ID		ENSG00000134215	ENSG00000067560
Uniprot IDs		Q9UKW4	P61586 Q9BVT0
PDB IDs		2D86	1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Wound Healing Regulation Of Intracellular Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Wounding Signal Transduction Cellular Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Platelet Activation Response To Fibroblast Growth Factor Regulation Of Phosphorylation Blood Coagulation Intracellular Signal Transduction Hemostasis Response To Organic Substance Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Axonogenesis Phosphatidylinositol 3-kinase Signaling Axon Development Regulation Of Immune Response Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Immune Response Regulation Of MAPK Cascade Axon Guidance Neuron Projection Morphogenesis	Positive Regulation Of Rho GTPase Activity Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Signaling Positive Regulation Of Ras GTPase Activity Regulation Of GTPase Activity Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Rho Protein Signal Transduction Response To Stimulus Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Apoptotic Process Programmed Cell Death Apoptotic Signaling Pathway Cell Death Death Regulation Of Cellular Process Regulation Of Apoptotic Process Ras Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Cell Death Locomotion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Positive Regulation Of Rac GTPase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Neuron Projection Development
Tagcloud ?		anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vinorelbine	1beta a549 acetyltransferase actinomycin bk bronchial c3 cat chloramphenicol constitutively cotransfection eliminated enhancer enhancers exoenzyme hoe immunoreactive kappab microg plasmid q63l reporter secreted stimulate stimulates supernatants t19n transferase
Tagcloud (Difference) ?		anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vinorelbine	1beta a549 acetyltransferase actinomycin bk bronchial c3 cat chloramphenicol constitutively cotransfection eliminated enhancer enhancers exoenzyme hoe immunoreactive kappab microg plasmid q63l reporter secreted stimulate stimulates supernatants t19n transferase
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