VAV3 and GAB1

Number of citations of the paper that reports this interaction (PubMedID 24728074)
77

Data Source:
BioGRID (pull down)

		VAV3	GAB1
Description		vav guanine nucleotide exchange factor 3	GRB2 associated binding protein 1
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane	Cytoplasm Cytosol Cell-cell Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Signaling Adaptor Activity
	Biological Process	Angiogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle Fusion DNA Damage Response Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Cell Projection Assembly Lamellipodium Assembly Platelet Activation Neutrophil Chemotaxis Positive Regulation Of B Cell Proliferation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Adhesion B Cell Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Intracellular Signal Transduction Endothelial Cell Chemotaxis Vascular Endothelial Growth Factor Signaling Pathway Vasodilation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Mechanical Stimulus
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Azathioprine ADME	PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Asthma and hay fever ( 24388013) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Differentiated thyroid cancer ( 28703219) Eosinophil percentage of white cells ( 32888494) Facial wrinkles (principal components analysis) ( 33959940) Hashimoto thyroiditis versus Graves' disease ( 25429627) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965 30367059 22493691) IgA nephropathy ( 25305756) Medication use (thyroid preparations) ( 31015401) Night sleep phenotypes ( 27126917) Papillary thyroid cancer ( 28703219) Plasma thyroid-stimulating hormone levels ( 24722205) Refractive error ( 32231278) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429)	Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Malaria ( 31844061) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		25 interacting genes: AR CBLB EGFR ERBB2 ERBB3 ERBB4 ESR1 GAB1 GRB2 IGF1R INSR KIT LCP2 MET PIK3R1 PLCG1 RAC1 RHOA RHOG RINT1 ROS1 SH3BP2 SHC1 ZRANB1 ZYX	74 interacting genes: AKT1 ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 WEE2-AS1 YAP1 YES1
Entrez ID		10451	2549
HPRD ID		05706	05116
Ensembl ID		ENSG00000134215	ENSG00000109458
Uniprot IDs		Q9UKW4	B7Z3B9 Q13480 Q9HA84
PDB IDs		2D86	4QSY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Tyrosine Kinase Activity Intracellular Signal Transduction Receptor Complex Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Neurotrophin TRKA Receptor Binding Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Insulin-like Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Insulin Receptor Substrate Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphate Metabolic Process Intracellular Signaling Cassette Regulation Of Developmental Process Protein Kinase Activity Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling ErbB-3 Class Receptor Binding Insulin Binding Positive Regulation Of Metabolic Process Plasma Membrane Positive Regulation Of Protein Phosphorylation ERBB2 Signaling Pathway Basal Plasma Membrane Positive Regulation Of Protein Modification Process Regulation Of Cell Migration Positive Regulation Of Phosphorylation Regulation Of Cell Motility	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Regulation Of Immune System Process ERBB Signaling Pathway Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Protein Kinase Activity Regulation Of Signal Transduction Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity B Cell Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Cell Activation Regulation Of MAPK Cascade Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Activation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Cytosol Positive Regulation Of MAPK Cascade Lymphocyte Activation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Migration Phosphorylation Insulin Receptor Signaling Pathway Immune Effector Process Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Immune System Process Receptor Tyrosine Kinase Binding Regulation Of Cell Adhesion
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