AKAP8 and ZNHIT1

		AKAP8	ZNHIT1
Description		A-kinase anchoring protein 8	zinc finger HIT-type containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Female Pronucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Nuclear Matrix	Nucleosome Swr1 Complex Nucleus Nucleoplasm
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding NF-kappaB Binding	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Histone Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Immune System Process Mitotic Chromosome Condensation Signal Transduction Protein Transport Negative Regulation Of Tumor Necrosis Factor Production Cell Cycle G2/M Phase Transition Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Heart Process Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of T Cell Proliferation Muscle Cell Differentiation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Transcription Initiation-coupled Chromatin Remodeling Calcium Ion Homeostasis Positive Regulation Of Transcription Initiation By RNA Polymerase II Hematopoietic Stem Cell Homeostasis Negative Regulation Of G0 To G1 Transition Positive Regulation Of Lymphoid Progenitor Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: AMY1A CASP3 CCND1 CCND2 CCND3 CSNK2A1 DDX5 FILNC1 MCM2 PRKAR2A RELA RNF10	23 interacting genes: APP BCL6 COL8A1 CSNK2B CYSRT1 DAPP1 FHL5 GOLGA6L9 GRB7 HINFP KANK2 KRTAP10-6 KRTAP10-7 KRTAP12-2 MAPK11 MAPK14 MAPK9 MDFI MYO5B OTX2 SH2D1A TNIP1 TP53
Entrez ID		10270	10467
HPRD ID		05258	15892
Ensembl ID		ENSG00000105127	ENSG00000106400
Uniprot IDs		O43823	O43257
PDB IDs			8X15 8X19 8X1C
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Amyloid-beta Formation Postsynapse To Nucleus Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Protein Serine/threonine Kinase Activator Activity Response To Radiation Regulation Of Amide Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Pre-mRNA Binding Liver Development Positive Regulation Of Amyloid-beta Formation Response To Ethanol Positive Regulation Of Cell Cycle Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Histone Deacetylase Binding Positive Regulation Of Mitotic Cell Cycle Response To Light Stimulus Positive Regulation Of Amyloid Precursor Protein Catabolic Process Execution Phase Of Apoptosis Negative Regulation Of Cell Cycle Positive Regulation Of Amide Metabolic Process Mitotic Cell Cycle Phase Transition Response To UV Regulation Of Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Enzyme Binding Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Response To Nicotine Regulation Of Cell Cycle Phase Transition MiRNA Transcription Protein Kinase Binding Postsynaptic Signal Transduction Response To Steroid Hormone Response To Ketone	Positive Regulation Of Reactive Oxygen Species Metabolic Process MAP Kinase Activity Cellular Senescence Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Cell Cycle Process Stress-induced Premature Senescence NLRP1 Inflammasome Complex Assembly Positive Regulation Of Apoptotic Signaling Pathway Defense Response Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Cytokine Production Identical Protein Binding Inflammatory Response Negative Regulation Of Cell Cycle Cellular Response To UV-B Regulation Of MiRNA Processing Intracellular Signaling Cassette Necroptotic Process Regulation Of Regulatory NcRNA Processing Cellular Response To Oxygen-containing Compound Protein Serine/threonine Kinase Activity Cellular Response To UV Regulation Of Inflammatory Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition MAPK Cascade DNA Damage Checkpoint Signaling Programmed Necrotic Cell Death Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cell Population Proliferation Regulation Of Transcription By RNA Polymerase II Molecular Function Activator Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of DNA Replication Cellular Response To Light Stimulus P38MAPK Cascade Response To UV-B Stress-activated MAPK Cascade Positive Regulation Of Myeloid Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA-mediated Gene Silencing
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