AKAP8 and CCND1

Number of citations of the paper that reports this interaction (PMID 14641107)
2

Data Source:
HPRD (in vivo)

		AKAP8	CCND1
Gene Name		A kinase (PRKA) anchor protein 8	cyclin D1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Female Pronucleus Nucleus Nucleoplasm Mitochondrion Golgi Apparatus Membrane Nuclear Matrix	Cyclin-dependent Protein Kinase Holoenzyme Complex Intracellular Nucleus Nucleoplasm Cytosol Tight Junction Membrane Transcriptional Repressor Complex
	Molecular Function	Double-stranded DNA Binding Zinc Ion Binding Protein Kinase A Regulatory Subunit Binding Poly(A) RNA Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding Proline-rich Region Binding
	Biological Process	Mitotic Nuclear Division Mitotic Chromosome Condensation Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Liver Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Response To Corticosterone Response To Calcium Ion Canonical Wnt Signaling Pathway Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest
Pathways			Chromatin organization Signaling by NOTCH Ubiquitin-dependent degradation of Cyclin D G1 Phase S Phase Cell Cycle, Mitotic RMTs methylate histone arginines Ubiquitin-dependent degradation of Cyclin D1 Cyclin D associated events in G1 Chromatin modifying enzymes Pre-NOTCH Transcription and Translation Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases
Drugs			Arsenic trioxide
Diseases
GWAS			Breast cancer ( 20453838) Breast size ( 22747683) Multiple myeloma (IgH translocation) ( 23502783)
Protein-Protein Interactions		10 interactors: AMY1A CASP3 CCND1 CCND2 CCND3 CSNK2A1 DDX5 MCM2 PRKAR2A RELA	60 interactors: AKAP8 AR ARID4A ATF2 BRCA1 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CRYAB CTNNB1 CUL3 DMTF1 EP300 ESR1 FBXO31 FBXO4 GSK3B HDAC3 HERC5 IFI27 INSM1 KAT2B LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PRKACA RABEP1 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SP1 STAT3 TAF1 THRA THRB TP73 TSC2 UBTF UHRF2 USP2 XPO1
Entrez ID		10270	595
HPRD ID		05258	01346
Ensembl ID		ENSG00000105127	ENSG00000110092
Uniprot IDs		M0QYL4 O43823	P24385 Q6FI00
PDB IDs			2W96 2W99 2W9F 2W9Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Response To UV Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Catalytic Activity Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Response To Light Stimulus Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Acetaldehyde Metabolic Process Cellular Response To Organic Substance Cell Division Response To Radiation Negative Regulation Of Cell Cycle Positive Regulation Of Schwann Cell Differentiation Response To Vitamin Cellular Response To Stimulus Negative Regulation Of Protein Catabolic Process Response To Drug Re-entry Into Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction Response To Cobalamin	Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Organic Substance Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Cycle Arrest Transcription, DNA-templated Cellular Response To Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Protein Kinase Activity RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Kinase Activity Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process
Tagcloud ?			11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold
Tagcloud (Difference) ?			11q13 4nqo 7f4 amplicon amplification amplified cavity chr distal example fgf3 fgf4 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold
Tagcloud (Intersection) ?