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AKAP8 and MCM2
Number of citations of the paper that reports this interaction (PMID
12740381
)
4
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
AKAP8
MCM2
Gene Name
A kinase (PRKA) anchor protein 8
minichromosome maintenance complex component 2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Condensed Chromosome
Female Pronucleus
Nucleus
Nucleoplasm
Mitochondrion
Golgi Apparatus
Membrane
Nuclear Matrix
Chromatin
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Cytoplasm
Microtubule Cytoskeleton
MCM Complex
Molecular Function
Double-stranded DNA Binding
Zinc Ion Binding
Protein Kinase A Regulatory Subunit Binding
Poly(A) RNA Binding
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Protein Binding
ATP Binding
Histone Binding
Metal Ion Binding
Biological Process
Mitotic Nuclear Division
Mitotic Chromosome Condensation
Signal Transduction
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Nucleosome Assembly
Cell Cycle
Cellular Response To Interleukin-4
Pathways
Synthesis of DNA
G2/M Checkpoints
Activation of the pre-replicative complex
DNA Replication Pre-Initiation
M/G1 Transition
Regulation of DNA replication
Activation of the pre-replicative complex
Orc1 removal from chromatin
S Phase
DNA strand elongation
Cell Cycle, Mitotic
Assembly of the pre-replicative complex
Orc1 removal from chromatin
G1/S Transition
Activation of ATR in response to replication stress
Cell Cycle Checkpoints
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
10 interactors:
AMY1A
CASP3
CCND1
CCND2
CCND3
CSNK2A1
DDX5
MCM2
PRKAR2A
RELA
47 interactors:
AKAP8
APP
ATM
ATR
CCNB2
CCNC
CDC6
CDC7
CDK2
CDK4
CDK6
CDKN2A
CPSF1
CSNK2A1
DBF4
ELL
GNB5
GTF2B
GTF2H1
HIST3H3
KAT7
MCM10
MCM3
MCM4
MCM5
MCM6
MCM7
MCPH1
MOB4
MPP3
ORC1
ORC2
ORC4
ORC5
ORC6
P2RX4
PHC2
PLK1
RAD52
RPA1
RPA2
RPA3
RPS4X
TBP
TCEA2
TERF1
TERF2IP
Entrez ID
10270
4171
HPRD ID
05258
00303
Ensembl ID
ENSG00000105127
ENSG00000073111
Uniprot IDs
M0QYL4
O43823
P49736
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of Protein Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Metabolic Process
Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Response To UV
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transferase Activity
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cellular Metabolic Process
Response To Growth Factor
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cell Cycle
Regulation Of Catalytic Activity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Cell Cycle
Positive Regulation Of Catalytic Activity
Regulation Of Metabolic Process
Positive Regulation Of Phosphorylation
Response To Light Stimulus
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Acetaldehyde Metabolic Process
Cellular Response To Organic Substance
Cell Division
Response To Radiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Schwann Cell Differentiation
Response To Vitamin
Cellular Response To Stimulus
Negative Regulation Of Protein Catabolic Process
Response To Drug
Re-entry Into Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Response To Tumor Necrosis Factor
Negative Regulation Of Protein Serine/threonine Kinase Activity
Signal Transduction
Response To Cobalamin
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Process
DNA Replication
Mitotic Cell Cycle
Cell Cycle Process
DNA Metabolic Process
Cell Cycle
DNA-dependent DNA Replication
DNA Replication Initiation
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Biosynthetic Process
Chromosome Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Cellular Metabolic Process
DNA Recombinase Assembly
Telomere Maintenance
Regulation Of Cell Cycle Process
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Positive Regulation Of Cell Cycle Process
Regulation Of Cellular Response To Heat
Positive Regulation Of Cell Cycle
Telomere Maintenance Via Telomere Lengthening
Cell Division
Cell Cycle Checkpoint
Double-strand Break Repair
Organelle Organization
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Cellular Response To DNA Damage Stimulus
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Nucleotide-excision Repair, DNA Damage Removal
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Tagcloud
?
1alpha
1beta
bcl2
carcinogenic
ccr2
cervices
e2
epithelia
hek293
hpv16
ikappabalpha
inflammation
intact
integration
isomerase
mediators
peptidyl
pin1
potentiated
prolyl
rela
sdf
ser727
squamous
stat3
stromal
supports
survivin
transformed
Tagcloud (Difference)
?
1alpha
1beta
bcl2
carcinogenic
ccr2
cervices
e2
epithelia
hek293
hpv16
ikappabalpha
inflammation
intact
integration
isomerase
mediators
peptidyl
pin1
potentiated
prolyl
rela
sdf
ser727
squamous
stat3
stromal
supports
survivin
transformed
Tagcloud (Intersection)
?