AKAP8 and B3GNT3

Data Source: HiPPIP (Novel)

		AKAP8	B3GNT3
Name		A-kinase anchoring protein 8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Female Pronucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Nuclear Matrix	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding NF-kappaB Binding	Protein Binding N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity
	Biological Process	Mitotic Cell Cycle Immune System Process Mitotic Chromosome Condensation Signal Transduction Protein Transport Negative Regulation Of Tumor Necrosis Factor Production Cell Cycle G2/M Phase Transition Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Poly-N-acetyllactosamine Biosynthetic Process
Pathways		None	Keratan sulfate biosynthesis O-linked glycosylation of mucins PD-L1(CD274) glycosylation and translocation to plasma membrane
GWAS		No GWAS studies recorded	Serum cancer antigen 19.9 levels ( 31666285 ) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485 ) Tumor biomarkers ( 23300138 )
Interacting Genes		12 interacting genes: AMY1A CASP3 CCND1 CCND2 CCND3 CSNK2A1 DDX5 FILNC1 MCM2 PRKAR2A RELA RNF10	None recorded
Entrez ID		10270	10331
HPRD ID		05258	10431
Ensembl ID		ENSG00000105127	ENSG00000179913
Uniprot IDs		O43823	Q9Y2A9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Amyloid-beta Formation Postsynapse To Nucleus Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Protein Serine/threonine Kinase Activator Activity Response To Radiation Regulation Of Amide Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Pre-mRNA Binding Liver Development Positive Regulation Of Amyloid-beta Formation Response To Ethanol Positive Regulation Of Cell Cycle Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Histone Deacetylase Binding Positive Regulation Of Mitotic Cell Cycle Response To Light Stimulus Positive Regulation Of Amyloid Precursor Protein Catabolic Process Execution Phase Of Apoptosis Negative Regulation Of Cell Cycle Positive Regulation Of Amide Metabolic Process Mitotic Cell Cycle Phase Transition Response To UV Regulation Of Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Enzyme Binding Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Response To Nicotine Regulation Of Cell Cycle Phase Transition MiRNA Transcription Protein Kinase Binding Postsynaptic Signal Transduction Response To Steroid Hormone Response To Ketone	Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Hemi-methylated DNA-binding Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric S-shaped Body Morphogenesis Cellular Response To Hormone Stimulus Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Diaphragm Development Regulation Of Female Gonad Development Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Metanephric Epithelium Development Muscle Cell Fate Commitment Nephron Tubule Morphogenesis Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Glomerulus Development Podocyte Differentiation C2H2 Zinc Finger Domain Binding Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Response To Hormone Female Pronucleus Male Genitalia Development Mesenchymal To Epithelial Transition Renal Tubule Morphogenesis Mitotic Chromosome Condensation Cellular Response To Prostaglandin E Stimulus Skeletal Muscle Organ Development Cellular Response To Gonadotropin Stimulus Sex Determination Cellular Response To Oxygen-containing Compound Circulatory System Development Reproductive System Development Adrenal Gland Development Protein Kinase A Regulatory Subunit Binding Cellular Response To Prostaglandin Stimulus Nucleolus Response To Prostaglandin E Response To Gonadotropin Regulation Of Animal Organ Formation Cell Differentiation Involved In Kidney Development NF-kappaB Binding