AKAP8 and DDX5

Number of citations of the paper that reports this interaction (PubMedID 11279182)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		AKAP8	DDX5
Description		A-kinase anchoring protein 8	DEAD-box helicase 5
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Female Pronucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Nuclear Matrix	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding NF-kappaB Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding MRNA 3'-UTR Binding Helicase Activity Protein Binding Calmodulin Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MH2 Domain Binding Pre-mRNA Binding Ribonucleoprotein Complex Binding SMAD Binding Calcium-dependent Protein Binding Nuclear Androgen Receptor Binding R-SMAD Binding Primary MiRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Mitotic Cell Cycle Immune System Process Mitotic Chromosome Condensation Signal Transduction Protein Transport Negative Regulation Of Tumor Necrosis Factor Production Cell Cycle G2/M Phase Transition Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing MRNA Transcription BMP Signaling Pathway Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Primary MiRNA Processing Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Viral Genome Replication Myoblast Differentiation Regulation Of Osteoblast Differentiation Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway MiRNA Transcription Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of MiRNA Transcription Regulation Of Skeletal Muscle Cell Differentiation
Pathways			SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome
Drugs			Artenimol
Diseases			Prostate cancer
GWAS			Lung function (FVC) ( 30804560) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: AMY1A CASP3 CCND1 CCND2 CCND3 CSNK2A1 DDX5 FILNC1 MCM2 PRKAR2A RELA RNF10	39 interacting genes: AKAP8 CALM1 CEBPA CREBBP DDX17 DUX4 ESR1 FBL FRS3 H19 HNRNPA0 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 LINC00624 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 OGT PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SLC26A4-AS1 SMAD3 SUMO2 TNNT1 TP53 UBE2I USP7 WBP11
Entrez ID		10270	1655
HPRD ID		05258	01615
Ensembl ID		ENSG00000105127	ENSG00000108654
Uniprot IDs		O43823	J3KTA4 P17844
PDB IDs			3FE2 4A4D
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Amyloid-beta Formation Postsynapse To Nucleus Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Protein Serine/threonine Kinase Activator Activity Response To Radiation Regulation Of Amide Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Pre-mRNA Binding Liver Development Positive Regulation Of Amyloid-beta Formation Response To Ethanol Positive Regulation Of Cell Cycle Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Histone Deacetylase Binding Positive Regulation Of Mitotic Cell Cycle Response To Light Stimulus Positive Regulation Of Amyloid Precursor Protein Catabolic Process Execution Phase Of Apoptosis Negative Regulation Of Cell Cycle Positive Regulation Of Amide Metabolic Process Mitotic Cell Cycle Phase Transition Response To UV Regulation Of Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Enzyme Binding Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Response To Nicotine Regulation Of Cell Cycle Phase Transition MiRNA Transcription Protein Kinase Binding Postsynaptic Signal Transduction Response To Steroid Hormone Response To Ketone	Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Regulation Of RNA Splicing Protein-containing Complex Negative Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Nucleic Acid Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Estrogen Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Presynaptic Cytosol Signal Transduction MRNA Processing Postsynaptic Cytosol Regulation Of MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Response To Lipid Transcription Regulator Complex Chromatin Remodeling Chromatin Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Processing Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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