AKAP8 and CNN1

		AKAP8	CNN1
Description		A-kinase anchoring protein 8	calponin 1
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Female Pronucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Nuclear Matrix	Cytoskeleton Focal Adhesion Actin Cytoskeleton
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding NF-kappaB Binding	Actin Binding Protein Binding Calmodulin Binding Actin Filament Binding
	Biological Process	Mitotic Cell Cycle Immune System Process Mitotic Chromosome Condensation Signal Transduction Protein Transport Negative Regulation Of Tumor Necrosis Factor Production Cell Cycle G2/M Phase Transition Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus	Regulation Of Smooth Muscle Contraction Actin Filament Organization Actomyosin Structure Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways			Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
Diseases
GWAS			Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		12 interacting genes: AMY1A CASP3 CCND1 CCND2 CCND3 CSNK2A1 DDX5 FILNC1 MCM2 PRKAR2A RELA RNF10	15 interacting genes: ACTA1 ADRB2 CALM1 CCHCR1 COG6 DNMBP FYN MYO1A NCAPD2 PLRG1 PRKCE SYCE1 TFPT TPM3 TUBB
Entrez ID		10270	1264
HPRD ID		05258	02884
Ensembl ID		ENSG00000105127	ENSG00000130176
Uniprot IDs		O43823	B7Z7E1 P51911 Q53FP8 V9HWA5
PDB IDs			1WYP
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Amyloid-beta Formation Postsynapse To Nucleus Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Protein Serine/threonine Kinase Activator Activity Response To Radiation Regulation Of Amide Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Pre-mRNA Binding Liver Development Positive Regulation Of Amyloid-beta Formation Response To Ethanol Positive Regulation Of Cell Cycle Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Histone Deacetylase Binding Positive Regulation Of Mitotic Cell Cycle Response To Light Stimulus Positive Regulation Of Amyloid Precursor Protein Catabolic Process Execution Phase Of Apoptosis Negative Regulation Of Cell Cycle Positive Regulation Of Amide Metabolic Process Mitotic Cell Cycle Phase Transition Response To UV Regulation Of Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Enzyme Binding Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Response To Nicotine Regulation Of Cell Cycle Phase Transition MiRNA Transcription Protein Kinase Binding Postsynaptic Signal Transduction Response To Steroid Hormone Response To Ketone	Actin Filament Chromosome Organization Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Body Mitotic Chromosome Condensation Cellular Response To Prostaglandin E Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Prostaglandin Stimulus Regulation Of Metal Ion Transport Response To Prostaglandin E Mitotic Cell Cycle Protein-containing Complex Binding Regulation Of Calcium Ion Transmembrane Transport Cell Cycle Phase Transition Fc-gamma Receptor Signaling Pathway Condensed Chromosome Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transport Innate Immune Response-activating Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Chromosome Condensation Cell Division Muscle Contraction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Activation Of Innate Immune Response Cytoplasm Sarcomere Cellular Response To Oxygen-containing Compound Positive Regulation Of Organelle Organization Modulation Of Chemical Synaptic Transmission Cell Cycle G2/M Phase Transition Regulation Of Calcium Ion Transport Fc Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Chromosome Organization Involved In Meiotic Cell Cycle Response To Amyloid-beta Beta2-adrenergic Receptor Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Glycine Ethanol Binding Regulation Of Chromosome Organization Muscle System Process
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