BRAP and CDC14A

Number of citations of the paper that reports this interaction (PMID 19152073)
1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		BRAP	CDC14A
Gene Name		BRCA1 associated protein	cell division cycle 14A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination	Cell Cycle Cell Proliferation Peptidyl-tyrosine Dephosphorylation Cell Division
Pathways			Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of mitotic cell cycle Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Drinking behavior ( 21372407) Esophageal cancer ( 19698717) Hematological and biochemical traits ( 20139978) Hypothyroidism ( 22493691) LDL cholesterol ( 20686565)
Protein-Protein Interactions		15 interactors: BRCA1 CDC14A CENPF CNKSR1 DDB1 HMG20A HRAS NUMA1 SYNE2 TRIM41 TRIM55 TRIM8 UBE2H USP15 USP4	8 interactors: BRAP CDC25B CDC6 CHRM1 FZR1 KIF20A POLR2A TP53
Entrez ID		8315	8556
HPRD ID		05405	04614
Ensembl ID		ENSG00000089234	ENSG00000079335
Uniprot IDs		Q59H81 Q7Z569	F5H7B3 Q59EF4 Q9UNH5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Viral Release From Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Organization Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cell Cycle Checkpoint Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Establishment Of Organelle Localization Negative Regulation Of Gene Expression Cell Cycle Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Negative Regulation Of Chromosome Organization Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Organelle Localization Regulation Of Mitotic Cell Cycle Protein Deubiquitination Regulation Of Cell Cycle Cell Division Cellular Protein Metabolic Process Nuclear Migration Along Microfilament G2/M Transition Of Mitotic Cell Cycle Protein Modification By Small Protein Removal Response To Radiation Negative Regulation Of Cell Cycle Nucleus Organization Chromosome Organization Positive Regulation Of Rac Protein Signal Transduction Cellular Response To Indole-3-methanol Cell Cycle Process Regulation Of Cell Cycle Process Cellular Metabolic Process Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Centriole Replication Positive Regulation Of DNA Metabolic Process Cytoskeleton Organization Regulation Of Viral Process	Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Mitotic Cell Cycle Regulation Of Cell Cycle Cell Division Cell Cycle Process Regulation Of Cell Cycle Process Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Proliferation Cell Cycle Checkpoint Regulation Of Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of DNA Replication Mitotic Nuclear Division Regulation Of Cytokinesis DNA Metabolic Process Regulation Of Mitotic Cell Cycle Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Negative Regulation Of Macromitophagy Transcription, RNA-templated Oligodendrocyte Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Positive Regulation Of Cell Division DNA Repair Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Helicase Activity Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway DNA Damage Checkpoint Cell Proliferation Traversing Start Control Point Of Mitotic Cell Cycle Organelle Organization Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Positive Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus Mitochondrial DNA Repair Activation Of Anaphase-promoting Complex Activity Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Positive Regulation Of Protein Modification Process
Tagcloud ?		centers cns complexity epistasis extraordinary fail fashion fate geographical graded gradients hyperactivation individualized ksr lis1 makes mapk midline mitogenic modulator nde1 overlapping overproliferation precision renew scaffold spatially spatiotemporally threshold	adhesion agilent bioinformatics cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic itgb6 oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice
Tagcloud (Difference) ?		centers cns complexity epistasis extraordinary fail fashion fate geographical graded gradients hyperactivation individualized ksr lis1 makes mapk midline mitogenic modulator nde1 overlapping overproliferation precision renew scaffold spatially spatiotemporally threshold	adhesion agilent bioinformatics cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic itgb6 oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice
Tagcloud (Intersection) ?