BRAP and SYNE2

Number of citations of the paper that reports this interaction (PMID 23707952)
1

Data Source:
BioGRID (two hybrid)

		BRAP	SYNE2
Gene Name		BRCA1 associated protein	spectrin repeat containing, nuclear envelope 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Nuclear Membrane	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Aggresome Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane LINC Complex Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination	Nuclear Envelope Organization Nuclear Migration Establishment Or Maintenance Of Cell Polarity Fibroblast Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Protein Localization To Nucleus Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane
Pathways			Meiotic synapsis
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Drinking behavior ( 21372407) Esophageal cancer ( 19698717) Hematological and biochemical traits ( 20139978) Hypothyroidism ( 22493691) LDL cholesterol ( 20686565)	Atrial fibrillation ( 22544366) Pulmonary function decline ( 22424883)
Protein-Protein Interactions		15 interactors: BRCA1 CDC14A CENPF CNKSR1 DDB1 HMG20A HRAS NUMA1 SYNE2 TRIM41 TRIM55 TRIM8 UBE2H USP15 USP4	7 interactors: ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 PML UBC
Entrez ID		8315	23224
HPRD ID		05405	09763
Ensembl ID		ENSG00000089234	ENSG00000054654
Uniprot IDs		Q59H81 Q7Z569	Q6MZP0 Q8WXH0
PDB IDs			4DXS 4FI9
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Viral Release From Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Organization Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cell Cycle Checkpoint Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Establishment Of Organelle Localization Negative Regulation Of Gene Expression Cell Cycle Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Negative Regulation Of Chromosome Organization Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Organelle Localization Regulation Of Mitotic Cell Cycle Protein Deubiquitination Regulation Of Cell Cycle Cell Division Cellular Protein Metabolic Process Nuclear Migration Along Microfilament G2/M Transition Of Mitotic Cell Cycle Protein Modification By Small Protein Removal Response To Radiation Negative Regulation Of Cell Cycle Nucleus Organization Chromosome Organization Positive Regulation Of Rac Protein Signal Transduction Cellular Response To Indole-3-methanol Cell Cycle Process Regulation Of Cell Cycle Process Cellular Metabolic Process Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Centriole Replication Positive Regulation Of DNA Metabolic Process Cytoskeleton Organization Regulation Of Viral Process	MAPK Cascade Signal Transduction By Phosphorylation Intracellular Signal Transduction Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Defense Response Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Fibroblast Growth Factor Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Cell Cycle Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cell Death
Tagcloud ?		centers cns complexity epistasis extraordinary fail fashion fate geographical graded gradients hyperactivation individualized ksr lis1 makes mapk midline mitogenic modulator nde1 overlapping overproliferation precision renew scaffold spatially spatiotemporally threshold	ago1 argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing unexpectedly
Tagcloud (Difference) ?		centers cns complexity epistasis extraordinary fail fashion fate geographical graded gradients hyperactivation individualized ksr lis1 makes mapk midline mitogenic modulator nde1 overproliferation precision renew scaffold spatially spatiotemporally threshold	ago1 argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna paradoxically prominent rather rnai rnas seq sirnas splicing unexpectedly
Tagcloud (Intersection) ?		overlapping