BRAP and SYNE2

Number of citations of the paper that reports this interaction (PubMedID 25820252)
30

Data Source:
BioGRID (two hybrid, two hybrid)

		BRAP	SYNE2
Description		BRCA1 associated protein	spectrin repeat containing nuclear envelope protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Fibrillar Center Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytoskeleton Plasma Membrane Focal Adhesion Cilium Membrane Sarcoplasmic Reticulum Myofibril Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly
Pathways		RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Meiotic synapsis
Drugs
Diseases			Emery-Dreifuss muscular dystrophy
GWAS		Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence ( 31591379) Alcohol dependence symptom count ( 29460428) Alcohol use disorder (consumption score) ( 30940813) Asthma ( 32296059 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Body mass index ( 25673413 26426971) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Coffee consumption ( 29367735) Colorectal cancer ( 26151821) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407) Epilepsy ( 33913524) Esophageal cancer ( 19698717) Fish consumption ( 32895509) Gastroesophageal reflux disease ( 31527586) Hematological and biochemical traits ( 20139978) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) LDL cholesterol ( 24097068 20686565) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 30226566) Parental lifespan ( 30642433) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25854761 28537254) Response to alcohol consumption (flushing response) ( 29460428) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum folate levels ( 29953918) Serum uric acid levels ( 29124443) Small vessel stroke (CCSp classification) ( 32047268) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Tumor necrosis factor levels ( 32805626) Waist-to-hip ratio adjusted for BMI ( 34021172 34054925) Weight ( 34054925)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 22544366 28416818 29892015 30061737) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480 32341527) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		42 interacting genes: AKAP3 APOA1 ATMIN BRCA1 BRK1 CCDC30 CDC14A CENPF CNKSR1 DDB1 DNMT1 FAM184A FBXO2 HMG20A HRAS ISG15 KSR1 LINC00852 NUMA1 PHLPP1 RBM12 SHCBP1L SKP2 SMARCE1 SYNE2 TANC2 TEKTL1 TEX35 TRIM41 TRIM55 TRIM8 UBB UBC UBE2D2 UBE2H UBE2L3 USP15 USP4 YJU2 ZNF382 ZNF479 ZNF521	12 interacting genes: ABI1 ACTC1 BRAP CALM1 CTNNB1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML RNF10 SASH1
Entrez ID		8315	23224
HPRD ID		05405	09763
Ensembl ID		ENSG00000089234	ENSG00000054654
Uniprot IDs		Q59H81 Q7Z569	Q8WXH0
PDB IDs			4DXS 4FI9 6XF1
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Nucleus Regulation Of Post-translational Protein Modification Protein Polyubiquitination Protein Tag Activity Regulation Of Protein Ubiquitination Modification-dependent Protein Catabolic Process Dynein Complex Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Cytokine-mediated Signaling Pathway Proteolysis Protein K48-linked Ubiquitination Ubiquitin-modified Histone Reader Activity Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Modification Process Regulation Of Signal Transduction Nucleoplasm Ubiquitin Protein Ligase Activity Regulation Of Cell Communication Regulation Of Signaling Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Organelle Organization Regulation Of Cell Cycle Phase Transition Microtubule-based Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling	Trachea Formation Positive Regulation Of Cell Communication Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Telomere Maintenance Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Nuclear Receptor-mediated Signaling Pathway Animal Organ Formation Regulation Of Nervous System Process Nuclear Steroid Receptor Activity Positive Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Hormone-mediated Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signaling Regulation Of Stress-activated MAPK Cascade Anatomical Structure Formation Involved In Morphogenesis Lamellipodium Protein Kinase Binding Post-translational Protein Modification Positive Regulation Of MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Regulation Of Cell Communication Regulation Of Calcium Ion Transport Regulation Of Signaling Regulation Of Telomere Maintenance Via Telomerase Thymus Development Glial Cell Fate Determination SMAD Binding Negative Regulation Of Gliogenesis Phosphatase Binding Regulation Of Myelination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Limb Development Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Negative Regulation Of Translation In Response To Oxidative Stress Dendrite Morphogenesis Sarcomere Glutamatergic Synapse Regulation Of System Process
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