BRAP and USP15

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		BRAP	USP15
Gene Name		BRCA1 associated protein	ubiquitin specific peptidase 15
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Nuclear Membrane	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitinated Histone Binding
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pathway-restricted SMAD Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Drinking behavior ( 21372407) Esophageal cancer ( 19698717) Hematological and biochemical traits ( 20139978) Hypothyroidism ( 22493691) LDL cholesterol ( 20686565)	Pulmonary function decline ( 22424883)
Protein-Protein Interactions		15 interactors: BRCA1 CDC14A CENPF CNKSR1 DDB1 HMG20A HRAS NUMA1 SYNE2 TRIM41 TRIM55 TRIM8 UBE2H USP15 USP4	45 interactors: BAP1 BMPR1A BRAP CARD9 CCDC57 FHL1 HIST2H2BE JOSD1 MAD1L1 OTUB1 PHF7 PLA2G2A RBCK1 RNF126 RNF144B SART3 SENP3 SENP8 SMAD3 SPDL1 STAM STK33 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UBE2S UCHL1 UCHL3 USP14 USP20 USP21 USP28 USP33 USP4 USP51 USP7 USP8 YOD1
Entrez ID		8315	9958
HPRD ID		05405	05293
Ensembl ID		ENSG00000089234	ENSG00000135655
Uniprot IDs		Q59H81 Q7Z569	Q9Y4E8
PDB IDs			1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Viral Release From Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Organization Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cell Cycle Checkpoint Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Establishment Of Organelle Localization Negative Regulation Of Gene Expression Cell Cycle Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Negative Regulation Of Chromosome Organization Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Organelle Localization Regulation Of Mitotic Cell Cycle Protein Deubiquitination Regulation Of Cell Cycle Cell Division Cellular Protein Metabolic Process Nuclear Migration Along Microfilament G2/M Transition Of Mitotic Cell Cycle Protein Modification By Small Protein Removal Response To Radiation Negative Regulation Of Cell Cycle Nucleus Organization Chromosome Organization Positive Regulation Of Rac Protein Signal Transduction Cellular Response To Indole-3-methanol Cell Cycle Process Regulation Of Cell Cycle Process Cellular Metabolic Process Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Centriole Replication Positive Regulation Of DNA Metabolic Process Cytoskeleton Organization Regulation Of Viral Process	Protein Modification By Small Protein Removal Protein Deubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteolysis Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K63-linked Deubiquitination Regulation Of Proteolysis Protein Polyubiquitination Histone Deubiquitination Protein K63-linked Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Stress Regulation Of Protein Ubiquitination Regulation Of Protein Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Protein Monoubiquitination Protein Autoubiquitination Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Pattern Recognition Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Innate Immune Response-activating Signal Transduction
Tagcloud ?		centers cns complexity epistasis extraordinary fail fashion fate geographical graded gradients hyperactivation individualized ksr lis1 makes mapk midline mitogenic modulator nde1 overlapping overproliferation precision renew scaffold spatially spatiotemporally threshold	antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin
Tagcloud (Difference) ?		centers cns complexity epistasis extraordinary fail fashion fate geographical graded gradients hyperactivation individualized ksr lis1 makes mapk midline mitogenic modulator nde1 overlapping overproliferation precision renew scaffold spatially spatiotemporally threshold	antitumor bacterial boost challenge characterized class crucial deficiency degradation deubiquitinases dub dubs e3 enhanced induce ligase mdm2 negatively nfatc2 physiological promoted regulated regulator responses stabilized targeting targets turn ubiquitin
Tagcloud (Intersection) ?