BRAP and UBE2L3

Number of citations of the paper that reports this interaction (PubMedID 29643511)
0

Data Source:
BioGRID (pull down)

		BRAP	UBE2L3
Description		BRCA1 associated protein	ubiquitin conjugating enzyme E2 L3
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination	Protein Polyubiquitination Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Cell Cycle Phase Transition Positive Regulation Of DNA-templated Transcription Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling Regulation of necroptotic cell death Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence ( 31591379) Alcohol dependence symptom count ( 29460428) Alcohol use disorder (consumption score) ( 30940813) Asthma ( 32296059 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Body mass index ( 25673413 26426971) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Coffee consumption ( 29367735) Colorectal cancer ( 26151821) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407) Epilepsy ( 33913524) Esophageal cancer ( 19698717) Fish consumption ( 32895509) Gastroesophageal reflux disease ( 31527586) Hematological and biochemical traits ( 20139978) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) LDL cholesterol ( 24097068 20686565) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 30226566) Parental lifespan ( 30642433) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25854761 28537254) Response to alcohol consumption (flushing response) ( 29460428) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum folate levels ( 29953918) Serum uric acid levels ( 29124443) Small vessel stroke (CCSp classification) ( 32047268) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Tumor necrosis factor levels ( 32805626) Waist-to-hip ratio adjusted for BMI ( 34021172 34054925) Weight ( 34054925)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Celiac disease ( 20190752 30572963 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 24097068 20686565 25961943) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepatitis B ( 24162738) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 20139978 29403010 28017375 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Psoriasis ( 23143594) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 21408207 23273568 26502338 27399966 28714469 19838193 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Total cholesterol levels ( 30275531) Ulcerative colitis ( 28067908)
Interacting Genes		42 interacting genes: AKAP3 APOA1 ATMIN BRCA1 BRK1 CCDC30 CDC14A CENPF CNKSR1 DDB1 DNMT1 FAM184A FBXO2 HMG20A HRAS ISG15 KSR1 LINC00852 NUMA1 PHLPP1 RBM12 SHCBP1L SKP2 SMARCE1 SYNE2 TANC2 TEKTL1 TEX35 TRIM41 TRIM55 TRIM8 UBB UBC UBE2D2 UBE2H UBE2L3 USP15 USP4 YJU2 ZNF382 ZNF479 ZNF521	113 interacting genes: ANKIB1 AREL1 ARIH1 ARIH2 ATXN3 BRAP BRCA1 CBL CBLB CBLC CCNB1IP1 CDC42 CDKN1B CUL5 CUL9 DTX3 FBXO2 FOS HACE1 HECTD1 HECTD2 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC3 HERC4 HERC6 HSPA4 HUWE1 IRF2BP1 ITCH LIG4 LTN1 MAPK6 MDM2 MEX3A MEX3C MID1 MKRN2 MKRN3 MUL1 MYCBP2 NEDD4 NEDD4L NFKBIA NR3C1 OTUD3 PIAS1 PIAS2 PJA1 POLR2A PRKN PTEN RBCK1 RBX1 RC3H1 RELA RNF103 RNF111 RNF113B RNF114 RNF125 RNF14 RNF144A RNF144B RNF150 RNF168 RNF170 RNF182 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF31 RNF7 RTF2 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TP53 TRAF6 TRAF7 TRIM13 TRIM21 TRIM23 TRIM25 TRIM28 TRIM31 TRIM39 TRIM55 TRIP12 UBA1 UBA5 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR4 UBR5 VPS11 WWP1 WWP2 XIAP
Entrez ID		8315	7332
HPRD ID		05405	04762
Ensembl ID		ENSG00000089234	ENSG00000185651
Uniprot IDs		Q59H81 Q7Z569	P68036
PDB IDs			1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13 6XXU 7B5L 7B5N 7OIK 7V8F 8EAZ 8EB0
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Nucleus Regulation Of Post-translational Protein Modification Protein Polyubiquitination Protein Tag Activity Regulation Of Protein Ubiquitination Modification-dependent Protein Catabolic Process Dynein Complex Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Cytokine-mediated Signaling Pathway Proteolysis Protein K48-linked Ubiquitination Ubiquitin-modified Histone Reader Activity Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Modification Process Regulation Of Signal Transduction Nucleoplasm Ubiquitin Protein Ligase Activity Regulation Of Cell Communication Regulation Of Signaling Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Organelle Organization Regulation Of Cell Cycle Phase Transition Microtubule-based Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Zinc Ion Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Cytoplasm Negative Regulation Of Signal Transduction Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K63-linked Ubiquitination Positive Regulation Of Catabolic Process Intracellular Signal Transduction Protein Monoubiquitination Cellular Response To Stress Regulation Of Signal Transduction Response To Stress Cytosol Intracellular Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
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