EIF4ENIF1 and HDGF

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		EIF4ENIF1	HDGF
Description		eukaryotic translation initiation factor 4E nuclear import factor 1	heparin binding growth factor
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding Actin Binding Protein Binding Growth Factor Activity Heparin Binding Tubulin Binding
	Biological Process	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Signal Transduction Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division
Pathways			XBP1(S) activates chaperone genes
Drugs			Copper
Diseases
GWAS		Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Blood protein levels ( 30072576) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Refractive error ( 32231278)
Interacting Genes		92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6	7 interacting genes: APP CEBPA EIF4ENIF1 GPR37 JUN SMAD4 XBP1
Entrez ID		56478	3068
HPRD ID		10456	02079
Ensembl ID		ENSG00000184708	ENSG00000143321
Uniprot IDs		Q9NRA8	A0A384NPW1 A8K8G0 B7Z958 P51858
PDB IDs		5ANR 6F9W 6X2R	1RI0 2NLU
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity	Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade RNA Polymerase II Transcription Regulator Complex Intracellular Signaling Cassette Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Gland Development Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Liver Development Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Signal Transduction Interleukin-6-mediated Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of RNA Metabolic Process Cell Maturation Neuron Projection Development Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Metal Ion Epithelial Cell Maturation SMAD Protein Signal Transduction Ubiquitin-like Protein Ligase Binding R-SMAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Microglial Cell Activation Carbohydrate Homeostasis Glucose Homeostasis Developmental Maturation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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