EIF4ENIF1 and MYO10

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		EIF4ENIF1	MYO10
Description		eukaryotic translation initiation factor 4E nuclear import factor 1	myosin X
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule	Ruffle Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Myosin Complex Lamellipodium Filopodium Filopodium Membrane Filopodium Tip Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cytoskeletal Protein Binding Spectrin Binding Protein-containing Complex Binding Actin Filament Binding Plus-end Directed Microfilament Motor Activity
	Biological Process	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA	Signal Transduction Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Regulation Of Filopodium Assembly
Pathways			Regulation of actin dynamics for phagocytic cup formation Netrin-1 signaling FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease ( 28044437) Circulating odd-numbered chain saturated fatty acid levels (C17:0) ( 29738550) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Normal facial asymmetry (deformation magnitude) ( 30631343) Obesity-related traits ( 23251661) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Polycystic ovary syndrome (adjusted for age) ( 34791234) Response to antidepressants (symptom remission) ( 29160301) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6	10 interacting genes: ACTA1 APOBEC3C CALM1 CALML3 DYNLL1 EIF4ENIF1 ITGB5 PELI2 PLA2G10 RAPH1
Entrez ID		56478	4651
HPRD ID		10456	03283
Ensembl ID		ENSG00000184708	ENSG00000145555
Uniprot IDs		Q9NRA8	B7Z3D4 Q9HD67
PDB IDs		5ANR 6F9W 6X2R	2LW9 3AU4 3AU5 3PZD 5I0H 5I0I 5KG8
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Detection Of Calcium Ion Calcineurin-mediated Signaling Myelin Sheath Dynein Intermediate Chain Binding Dynein Complex Substantia Nigra Development Filopodium Cytoskeleton Sarcomere Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Integrin Alphav-beta5 Complex Platelet Activating Factor Catabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
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