EIF4ENIF1 and EIF4E

Number of citations of the paper that reports this interaction (PubMedID 10856257)
82

Data Source:
HPRD (in vitro, in vivo)

		EIF4ENIF1	EIF4E
Description		eukaryotic translation initiation factor 4E nuclear import factor 1	eukaryotic translation initiation factor 4E
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Nuclear Body Nuclear Speck Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding MRNA Cap Binding DNA-binding Transcription Factor Binding
	Biological Process	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle MRNA Transport Nuclear Export Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Pathways			ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs			7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)	Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol dependence ( 33290381) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels ( 32203549) Mean arterial pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Menopause (age at onset) ( 29773799) Sensation seeking ( 30718321)
Interacting Genes		92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6	38 interacting genes: ACVRL1 APP BIRC2 CD83 CEBPA CPEB1 CYFIP1 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 EN2 GEMIN5 HOXA9 IPO8 KANK2 LRPPRC MAPKAPK5 MKNK1 MKNK2 OTX2 PML PRDM4 PRKCA PRKCB PRKCG PTEN RNMT TDO2 TLX1 TRIM27 UBXN11 XPO1
Entrez ID		56478	1977
HPRD ID		10456	00591
Ensembl ID		ENSG00000184708	ENSG00000151247
Uniprot IDs		Q9NRA8	D6RBW1 P06730 Q32Q75 X5D7E3
PDB IDs		5ANR 6F9W 6X2R	1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML 7D6Y 7D8B 7EZW 7F07 7MEU 7XTP 8QM4 8QM5 8QM6 8QM7 8QM8 8QM9 8SX4 9DON
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity	Regulation Of Translation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Eukaryotic Initiation Factor 4E Binding Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translational Initiation Negative Regulation Of Translation Negative Regulation Of Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Translation Repressor Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Translation Factor Activity, RNA Binding Positive Regulation Of Biosynthetic Process Calcium-dependent Protein Serine/threonine Kinase Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Translation Negative Regulation Of Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translational Initiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Translation Initiation Factor Activity PML Body Histone H3T6 Kinase Activity Cognition Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Cell Cycle Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Learning Or Memory Translational Initiation
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