CCND2 and ARID5B

Data Source: HiPPIP (Novel)

		CCND2	ARID5B
Name		cyclin D2	AT-rich interaction domain 5B
Structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Membrane Cyclin D2-CDK4 Complex	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Cell Division Regulation Of Cell Cycle Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Cellular Response To Leukemia Inhibitory Factor
Pathways		Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity	HDMs demethylate histones
Diseases		Testicular cancer	None
GWAS		Alanine aminotransferase levels ( 34315874 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 34315874 ) Birth weight ( 31043758 ) Blond vs. brown/black hair color ( 30531825 ) Blood glucose levels ( 31928498 ) Brown vs. black hair color ( 30531825 ) Colorectal cancer ( 24836286 31826910 26151821 30529582 23266556 23263487 ) Colorectal cancer or advanced adenoma ( 30510241 ) Glucocorticoid-induced osteonecrosis ( 26265699 ) Height ( 28270201 28552196 ) Low density lipoprotein cholesterol levels ( 32154731 ) Major depressive disorder ( 19107115 23377640 ) Mean corpuscular hemoglobin ( 28017375 ) Mean corpuscular volume ( 28017375 ) Obesity-related traits ( 23251661 ) Offspring birth weight ( 31043758 ) Pulse pressure ( 27841878 30578418 ) QT interval (drug interaction) ( 23459443 ) Red blood cell count ( 20139978 28017375 ) Red blood cell traits ( 23222517 ) Smoking behaviour (cigarettes smoked per day) ( 30679032 ) Triglyceride levels ( 31928498 32154731 32203549 ) Type 2 diabetes ( 30297969 31118516 30054458 29358691 28869590 32499647 22885922 ) Waist circumference ( 31928498 )	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088 ) Acute lymphoblastic leukemia (childhood) ( 19684603 19684604 22076464 29348612 33891562 28817678 25310577 23512250 ) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 ) Appendicular lean mass ( 33097823 ) Autoimmune thyroid disease ( 32581359 ) Automobile speeding propensity ( 30643258 ) B-cell acute lymphoblastic leukaemia ( 31767839 ) Blood urea nitrogen levels ( 31152163 ) Central corneal thickness ( 32528159 31798171 30894546 29760442 ) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025 ) Corneal resistance factor ( 30894546 ) Corneal structure ( 23291589 ) Diastolic blood pressure ( 19430483 ) Estimated glomerular filtration rate ( 31152163 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gout ( 32238385 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Intraocular pressure ( 29235454 29617998 ) Intraocular pressure (Goldman correlated) ( 30894546 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Neutrophil percentage of white cells ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Reaction time ( 29844566 ) Response to haloperidol in psychosis ( 24751813 ) Rheumatoid arthritis ( 22446963 23143596 24390342 30423114 32723749 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Serum metabolite levels ( 33031748 ) Serum total protein levels ( 23022100 ) Smoking initiation ( 33082346 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Systemic lupus erythematosus ( 26502338 27399966 33272962 23273568 ) Tinnitus ( 33742053 ) Triglyceride levels ( 32154731 32203549 ) Type 2 diabetes ( 32499647 ) Vitiligo ( 27723757 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		3 novel interactors: ARID5B CD27 MAD1L1	9 novel interactors: ANXA7 CAMK2G CCND2 LZTS1 NRBF2 RHOBTB1 RIOX2 SLC22A1 USP54
Interacting Genes		64 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2	1 interacting genes: RUNX1
Entrez ID		894	84159
HPRD ID		00451	18880
Ensembl ID		ENSG00000118971	ENSG00000150347
Uniprot IDs		P30279	Q14865
PDB IDs		6EI2	1IG6 2OEH
GO Terms Enriched among Interactors		Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase Binding Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Developmental Process Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Growth Regulation Of Apoptotic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Cellular Senescence Regulation Of Catalytic Activity Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Developmental Process Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cell Differentiation	None