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CCND2 and FBXL2
Number of citations of the paper that reports this interaction (PubMedID
22323446
)
55
Data Source:
BioGRID
(enzymatic study)
CCND2
FBXL2
Description
cyclin D2
F-box and leucine rich repeat protein 2
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Microtubule Organizing Center
Cytosol
Membrane
Nuclear Membrane
Cyclin D2-CDK4 Complex
Cytoplasm
Membrane
SCF Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Protein Serine/threonine Kinase Activator Activity
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Protein Binding
Calmodulin Binding
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Long-term Memory
Positive Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Apoptotic Process
Cell Division
Regulation Of Cell Cycle
Cellular Response To X-ray
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Regulation Of Autophagy
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Defense Response
Protein Modification Process
Host-mediated Perturbation Of Viral RNA Genome Replication
Regulation Of Inflammatory Response
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways
Cyclin D associated events in G1
Regulation of RUNX1 Expression and Activity
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drug-mediated inhibition of CDK4/CDK6 activity
Drugs
Diseases
Testicular cancer
GWAS
Alanine aminotransferase levels (
34315874
)
Appendicular lean mass (
33097823
)
Aspartate aminotransferase levels (
34315874
)
Birth weight (
31043758
)
Blond vs. brown/black hair color (
30531825
)
Blood glucose levels (
31928498
)
Brown vs. black hair color (
30531825
)
Colorectal cancer (
24836286
31826910
26151821
30529582
23266556
23263487
)
Colorectal cancer or advanced adenoma (
30510241
)
Glucocorticoid-induced osteonecrosis (
26265699
)
Height (
28270201
28552196
)
Low density lipoprotein cholesterol levels (
32154731
)
Major depressive disorder (
19107115
23377640
)
Mean corpuscular hemoglobin (
28017375
)
Mean corpuscular volume (
28017375
)
Obesity-related traits (
23251661
)
Offspring birth weight (
31043758
)
Pulse pressure (
27841878
30578418
)
QT interval (drug interaction) (
23459443
)
Red blood cell count (
20139978
28017375
)
Red blood cell traits (
23222517
)
Smoking behaviour (cigarettes smoked per day) (
30679032
)
Triglyceride levels (
31928498
32154731
32203549
)
Type 2 diabetes (
30297969
31118516
30054458
29358691
28869590
32499647
22885922
)
Waist circumference (
31928498
)
Heel bone mineral density (
30598549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Rostral anterior cingulate cortex volume (
31530798
)
Interacting Genes
64 interacting genes:
ABCB5
ABL1
ADRB2
AKAP8
AKT1
ARAF
ARNT
AURKA
BECN1
CALM1
CALM2
CALM3
CBLC
CCNE1
CD44
CDK4
CDK5
CDK6
CDK7
CDKN1A
CDKN1B
CDKN2A
CDKN2B
CDKN2C
DMTF1
EPHA2
ERBB2
FBXL2
FGFR4
FZR1
GLIS2
GRM1
H1-1
HGF
HIF1A
KAT2A
KDELR2
LATS2
MAP2K3
MAP2K5
MAP2K6
MAP3K5
MAPK14
MET
NF2
NPDC1
PCGF2
PDGFRA
PIK3CA
PSMD10
PTEN
RAF1
RASSF1
RB1
RELA
RUNX1
SERTAD1
STK11
TEAD2
TERT
TEX11
TNFRSF1A
TSC1
TTYH2
14 interacting genes:
APP
AURKB
CCND2
CDC34
COL7A1
EGFR
IL1B
NLRP3
PIK3R2
RBX1
SKP1
UBE2D1
UBE2D3
UBE2G1
Entrez ID
894
25827
HPRD ID
00451
05736
Ensembl ID
ENSG00000118971
ENSG00000153558
Uniprot IDs
P30279
B4E1B8
Q9UKC9
PDB IDs
6EI2
6O60
Enriched GO Terms of Interacting Partners
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Regulation Of Cell Cycle
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Animal Organ Development
Regulation Of Cell Communication
Regulation Of Signaling
Kinase Activity
Signal Transduction
Protein Kinase Activity
Regulation Of Cell Cycle Process
Regulation Of Cell Population Proliferation
Intracellular Signal Transduction
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Modification Process
Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Intracellular Signaling Cassette
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Kinase Binding
Protein Serine/threonine Kinase Activity
Regulation Of Mitotic Cell Cycle Phase Transition
Developmental Process
Positive Regulation Of Signal Transduction
Protein Serine Kinase Activity
Regulation Of Growth
Regulation Of Apoptotic Process
Cell Cycle Phase Transition
Negative Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Process
Cellular Senescence
Regulation Of Catalytic Activity
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Apoptotic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Developmental Process
Apoptotic Process
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Programmed Cell Death
Cell Death
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Metabolic Process
Regulation Of Cell Differentiation
Cellular Response To Stress
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cell Cycle
Cell Differentiation
Protein K48-linked Ubiquitination
Ubiquitin Conjugating Enzyme Activity
Regulation Of Mitotic Cell Cycle
Protein Polyubiquitination
Positive Regulation Of Cell Cycle
Negative Regulation Of Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Signaling
Cytosol
Negative Regulation Of Cell Communication
Ubiquitin-protein Transferase Activity
Proteasomal Protein Catabolic Process
Positive Regulation Of Cell Cycle Process
Post-translational Protein Modification
Cul7-RING Ubiquitin Ligase Complex
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
ATP Binding
Protein Catabolic Process
Protein Ubiquitination
Regulation Of Intracellular Signal Transduction
Cell Cycle Phase Transition
Regulation Of Cell Cycle
Proteolysis Involved In Protein Catabolic Process
Protein Monoubiquitination
Protein Modification By Small Protein Conjugation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Response To Radiation
Negative Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Regulation Of Signal Transduction
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Intracellular Signal Transduction
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Transcription By RNA Polymerase II
Cellular Response To Oxygen-containing Compound
Apoptotic Process
Programmed Cell Death
Cell Death
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Non-canonical NF-kappaB Signal Transduction
Regulation Of Apoptotic Process
Astrocyte Activation
Positive Regulation Of Cell Cycle Checkpoint
Regulation Of Programmed Cell Death
Regulation Of Cell Communication
Regulation Of Signaling
Response To Light Stimulus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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