PGD

Description		phosphogluconate dehydrogenase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Phosphogluconate Dehydrogenase (decarboxylating) Activity Oxidoreductase Activity Carbohydrate Binding Carboxylic Acid Binding NADP Binding
	Biological Process	Pentose-phosphate Shunt NADP+ Metabolic Process NADPH Regeneration Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process D-gluconate Metabolic Process
Pathways		Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs		Gadopentetic acid Dacarbazine Ketotifen 6-phospho-D-gluconic acid Nicotinamide 8-bromo-adenine dinucleotide phosphate
Diseases
GWAS		Hemoglobin ( 32888494) Hepatocellular carcinoma ( 20676096) Metabolite levels ( 23823483)
Novel Interacting Genes		2 novel interacting genes: ALG5 OS9
Interacting Genes		8 interacting genes: CDC42 CDK4 GBE1 LINC00632 LINC01554 LSM8 OGT TERF1
Entrez ID		5226
HPRD ID		01391
Ensembl ID		ENSG00000142657
Uniprot IDs		B4E2U0 P52209
PDB IDs		2JKV 4GWG 4GWK 5UQ9
Enriched GO Terms of Interacting Partners?		Glycosyltransferase Activity 1,4-alpha-glucan Branching Enzyme Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glycosylation-dependent Protein Binding Dolichyl-phosphate Beta-glucosyltransferase Activity GBD Domain Binding Storage Vacuole Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
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