PGD and GBE1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PGD	GBE1
Gene Name		phosphogluconate dehydrogenase	glucan (1,4-alpha-), branching enzyme 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Extracellular Vesicular Exosome	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Phosphogluconate Dehydrogenase (decarboxylating) Activity NADP Binding	1,4-alpha-glucan Branching Enzyme Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Cation Binding
	Biological Process	Carbohydrate Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Oxidative Branch Pathogenesis Pentose Biosynthetic Process D-gluconate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Pathogenesis Small Molecule Metabolic Process
Pathways		Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Pentose phosphate pathway (hexose monophosphate shunt)	Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS		Hepatocellular carcinoma ( 20676096)
Protein-Protein Interactions		4 interactors: CDK4 GBE1 LSM8 TERF1	4 interactors: EPHB3 PGD PRMT6 TRDMT1
Entrez ID		5226	2632
HPRD ID		01391	01985
Ensembl ID		ENSG00000142657	ENSG00000114480
Uniprot IDs		P52209	E9PGM4 Q04446 Q59ET0
PDB IDs		2JKV 4GWG 4GWK	4BZY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Telomere Maintenance Via Telomere Shortening Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Negative Regulation Of Telomerase Activity Positive Regulation Of Cell Size Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Mitotic Cell Cycle Regulation Of Telomere Maintenance Via Telomerase Cell Division Negative Regulation Of Cell Cycle Positive Regulation Of Microtubule Polymerization Regulation Of Cell Cycle Process Regulation Of Telomerase Activity Response To Drug Regulation Of Telomere Maintenance Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death RNA-dependent DNA Replication Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle Arrest Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Lead Ion Glycogen Biosynthetic Process Response To Hyperoxia Mitotic Cell Cycle Process Regulation Of Microtubule Polymerization Chromatin Organization Telomere Maintenance Via Telomere Lengthening Response To Testosterone Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Cellular Polysaccharide Biosynthetic Process Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Polysaccharide Biosynthetic Process	D-gluconate Metabolic Process Histone H3-R2 Methylation Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process C-5 Methylation Of Cytosine Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Methylation DNA Methylation On Cytosine Dendritic Spine Morphogenesis Histone H4-R3 Methylation Peptidyl-arginine N-methylation Corpus Callosum Development Dendritic Spine Development Pentose-phosphate Shunt Dendritic Spine Organization Histone Arginine Methylation Retinal Ganglion Cell Axon Guidance Peptidyl-arginine Methylation Glyceraldehyde-3-phosphate Metabolic Process Regulation Of Rac GTPase Activity TRNA Methylation Axonal Fasciculation Regulation Of Cdc42 GTPase Activity Regulation Of Cdc42 Protein Signal Transduction Glucose 6-phosphate Metabolic Process Positive Regulation Of Synapse Assembly Response To Amphetamine NADP Metabolic Process Neuron Recognition Regulation Of Rac Protein Signal Transduction Central Nervous System Projection Neuron Axonogenesis Substrate Adhesion-dependent Cell Spreading
Tagcloud ?		a2 achieved actions advances bk1 bk2 bk3 bk4 bradykinin characterization detail diverse ep1 ep2 ep3 ep4 exert hypertension pge prostacyclin prostaglandin prostanoid prostanoids remarkable reviewed subtypes thromboxane versatile	amylopectin branching cardiomyocyte cardiomyocytes compaction contrary e609x expectations fetal fetalis glycogen gsd hearts hydrops hypertrabeculation lethality manifestation noncompaction osmotic pathogenetic polysaccharide presumably recapitulated recessive stop swelling trabeculation ventricular
Tagcloud (Difference) ?		a2 achieved actions advances bk1 bk2 bk3 bk4 bradykinin characterization detail diverse ep1 ep2 ep3 ep4 exert hypertension pge prostacyclin prostaglandin prostanoid prostanoids remarkable reviewed subtypes thromboxane versatile	amylopectin branching cardiomyocyte cardiomyocytes compaction contrary e609x expectations fetal fetalis glycogen gsd hearts hydrops hypertrabeculation lethality manifestation noncompaction osmotic pathogenetic polysaccharide presumably recapitulated recessive stop swelling trabeculation ventricular
Tagcloud (Intersection) ?