TRIM23 and TRIM31

Number of citations of the paper that reports this interaction (PubMedID 11331580)
63

Data Source:
HPRD (two hybrid)

		TRIM23	TRIM31
Description		tripartite motif containing 23	tripartite motif containing 31
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Endomembrane System Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity Ubiquitin-protein Transferase Activity Protein Binding GTP Binding Enzyme Activator Activity Zinc Ion Binding Transferase Activity GDP Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Intracellular Protein Transport Positive Regulation Of Autophagy Vesicle-mediated Transport Protein Ubiquitination Innate Immune Response	Immune System Process Ubiquitin-dependent Protein Catabolic Process Inflammatory Response Protein Ubiquitination Viral Release From Host Cell Negative Regulation Of Viral Transcription NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Anger ( 24489884) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Chronic obstructive pulmonary disease ( 33909500) Estimated glomerular filtration rate in diabetes ( 31451708) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Isovolumetric relaxation time ( 28394258) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252) Neuroticism ( 29255261) Prostate cancer ( 25217961) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 32771030) Takayasu arteritis ( 33308445) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		219 interacting genes: ACTN4 AKTIP ANKRD36BP1 ANKRD55 ANO1 AP3M1 AQP1 ARFGAP1 ARHGEF3 ARNT2 ATPAF2 ATXN7 BAG1 BAZ2B BICRAL BRME1 C8orf33 CARD9 CATSPERT CBX8 CCDC13 CCDC146 CCDC25 CCDC33 CDC20B CDC73 CDR2 CFAP53 CHP1P2 CIMIP4 COX5B CPNE7 CREB5 CSRP2 CWF19L2 CXCL14 CYTH1 CYTH2 DCX DEPP1 DMC1 DMRT3 DNAAF4 DOCK2 EAF2 EHHADH EIF3D ENKD1 EPN2 EXOC3-AS1 FAM110A FAM133A FAM193B FAM83A FAM90A1 FBF1 FHIT FLAD1 FXR2 GAD1 GATA2 GCC2-AS1 GEM GGA2 GGA3 GLIDR GMCL2 GPANK1 GPKOW HAPLN2 HAUS1 HGS HNRNPLL HOXB5 HSPB7 IL16 IQCE IQUB JOSD1 JRK KAT5 KIFC3 KLHL42 KRT6A KRT75 KRT76 LAGE3 LENG1 LGALS14 LGALS3 LGALS8 LINC00526 LINC01018 LMO2 LMO3 LNX1 MDM2 MKRN3 MLH1 MORN4 MRPL4 MRPL45 MSRB3 MTFR2 MYEF2 MYOM1 MYOZ1 NAB2 NEDD9 NEK6 NFU1 NOXA1 NTAQ1 NUDT21 NXT2 PDE4D PHF1 PIAS2 PIK3R2 PITX1 PKP4 PLEKHA2 POLI POLL POM121 PPIL2 PPP1R15B PPP1R18 PRPF18 PRPF31 PSMA1 PSMB1 RAD18 RAMAC RCAN3 RIBC1 RIBC2 RIN1 RNF126 RNF213 RNF32 RNF34 RNF6 RSRC2 RTP5 RUFY1 SCNM1 SF1 SH2D4A SIAH1 SIRPA SLC25A6 SMG9 SNAI1 SNAI2 SNRPB SNRPB2 SNW1 SORBS3 SPG21 SUMO1P1 TACO1 TASOR2 TBC1D22B TCEA2 TCEANC TEPSIN TMSB4X TNFAIP3 TRAF1 TRAIP TRIM27 TRIM29 TRIM31 TRIM32 TRIM42 TRIM55 TRIM63 TROAP TSEN54 TSG101 TSHZ3 TXNDC5 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U UBE2W UBOX5 UBQLN1 USP2 USP20 USP21 UTP23 VGLL1 WDR25 WHR1 ZBTB16 ZBTB4 ZC2HC1C ZFAND2A ZNF20 ZNF250 ZNF408 ZNF417 ZNF474 ZNF564 ZNF581 ZNF587 ZNF688 ZNF835	26 interacting genes: CCT6A CFLAR EID3 IKBKG MAGEA1 MAGEA2B MAVS MKRN3 MNAT1 NSMCE4A RHBDF2 SYK TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2N UBE2W USP7 ZSCAN1
Entrez ID		373	11074
HPRD ID		03449	10281
Ensembl ID		ENSG00000113595	ENSG00000204616
Uniprot IDs		P36406	Q2L6J1 Q9BZY9
PDB IDs		5VZV 5VZW	2YSJ 2YSL
Enriched GO Terms of Interacting Partners?		Protein Binding Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Nucleus Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activator Activity Macromolecule Catabolic Process Protein Monoubiquitination Proteolysis Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding SUMO Transferase Activity Spliceosomal Complex Nuclear Speck Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Establishment Of Protein Localization To Vacuole MRNA Processing Spindle Pole Identical Protein Binding Protein Metabolic Process Metal Ion Binding SnRNP Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Striated Muscle Myosin Thick Filament Cytoplasm Protein Sumoylation	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Protein Ubiquitination Protein Modification Process TORC1 Signaling Protein Metabolic Process TOR Signaling Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Transferase Activity Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Binding Regulation Of TORC1 Signaling Ubiquitin Ligase Complex Regulation Of Metabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process DNA Damage Response Macromolecule Catabolic Process Regulation Of TOR Signaling ATP Binding Nucleotide Binding Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Autophagy Regulation Of Macromolecule Metabolic Process Regulation Of DNA-binding Transcription Factor Activity DNA Repair Cellular Response To Stress Defense Response To Symbiont Defense Response To Other Organism Response To Stress Nucleus Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Telomere Maintenance Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Establishment Of Protein Localization To Telomere
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