WASF2 and GAS7

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		WASF2	GAS7
Gene Name		WAS protein family, member 2	growth arrest-specific 7
Image
Gene Ontology Annotations	Cellular Component	Ruffle Intracellular Early Endosome Cytosol Cell-cell Junction Actin Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome	Ruffle Cytoplasm Actin Filament
	Molecular Function	Actin Binding Protein Binding Protein Complex Binding	Sequence-specific DNA Binding Transcription Factor Activity Actin Filament Binding
	Biological Process	Angiogenesis Ameboidal-type Cell Migration Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis	Regulation Of Transcription, DNA-templated Cell Cycle Arrest Regulation Of Cell Shape Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament Bundle Assembly
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Intraocular pressure ( 22570627)
Protein-Protein Interactions		23 interactors: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1	22 interactors: ABI1 ACTA1 APBB1IP ATXN1L CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH HNRNPU KHDRBS1 NCKAP1 NCKAP1L PACSIN1 RPLP0 SF1 SF3A1 SFPQ WAS WASF2 WDYHV1
Entrez ID		10163	8522
HPRD ID		05796	16011
Ensembl ID		ENSG00000158195	ENSG00000007237
Uniprot IDs		Q9Y6W5	B7Z1Q2 O60861
PDB IDs		2A40	2LX7 2YSH
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Vesicle-mediated Transport Neuron Projection Development Cell Projection Morphogenesis Neuron Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Neuron Development Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament Organization Cell Morphogenesis Defense Response Neuron Differentiation Cell Development Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Immune System Process Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Actin Filament-based Process Generation Of Neurons Locomotion Cell Morphogenesis Involved In Differentiation Neurogenesis Immune System Process Cytoskeleton Organization Chemotaxis Nervous System Development Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization	Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Lamellipodium Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Nucleation Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Actin Filament Organization MRNA Metabolic Process Lamellipodium Morphogenesis MRNA 3'-splice Site Recognition Positive Regulation Of Immune System Process Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Immune Response Endocytosis Cellular Component Assembly Actin Filament-based Movement Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Organelle Organization MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization Innate Immune Response Regulation Of Cytoskeleton Organization Cellular Response To Stimulus Positive Regulation Of Lamellipodium Assembly Regulation Of Immune Response Megakaryocyte Development Regulation Of Immune System Process Positive Regulation Of Lamellipodium Organization RNA Processing Regulation Of Cellular Component Organization Vesicle-mediated Transport Megakaryocyte Differentiation Regulation Of Lamellipodium Assembly Movement Of Cell Or Subcellular Component
Tagcloud ?			as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Difference) ?			as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Intersection) ?