WASF2 and ACTR3

Number of citations of the paper that reports this interaction (PubMedID 9889097)
0

Data Source:
HPRD (in vitro, in vivo)

		WASF2	ACTR3
Description		WASP family member 2	actin related protein 3
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Actin Cytoskeleton Membrane Basolateral Plasma Membrane Lamellipodium SCAR Complex Protein-containing Complex Cell Projection Synapse Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Site Of Double-strand Break Cell Projection Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase A Regulatory Subunit Binding Cadherin Binding Protein Kinase A Binding Arp2/3 Complex Binding	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Angiogenesis Ameboidal-type Cell Migration Neuron Migration Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Cell Motility Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis Postsynaptic Actin Cytoskeleton Organization Postsynapse Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cell Projection Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Actin Polymerization-dependent Cell Motility Cellular Response To Type II Interferon
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Systolic blood pressure ( 30578418)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Systolic blood pressure in sickle cell anemia ( 24058526) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		24 interacting genes: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1 WWP2	18 interacting genes: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN ERCC6 HCLS1 JUND LINC01554 OGT SHARPIN UBE3A WASF2 WASF3 WASL
Entrez ID		10163	10096
HPRD ID		05796	05024
Ensembl ID		ENSG00000158195	ENSG00000115091
Uniprot IDs		Q9Y6W5	B4DXW1 P61158
PDB IDs		2A40	6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Lamellipodium Cell Projection Organization SCAR Complex Regulation Of Lamellipodium Assembly Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Actin Filament Organization Neuron Projection Morphogenesis Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Cell Motility Regulation Of Synapse Organization Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Supramolecular Fiber Organization Endocytosis Actin-based Cell Projection Positive Regulation Of Cytoskeleton Organization Arp2/3 Protein Complex Cell Projection Cytoskeleton Organization Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Postsynapse Peptidyl-tyrosine Phosphorylation Regulation Of Cell Projection Assembly Regulation Of Actin Filament Polymerization Actin Filament-based Process Identical Protein Binding Import Into Cell Cell Leading Edge Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Neuron Projection Development Regulation Of Actin Filament Length Cell Migration Actin Cytoskeleton	Arp2/3 Protein Complex Actin Filament Organization Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Actin Nucleation Regulation Of Actin Filament Organization Actin Cytoskeleton Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Binding Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Actin Cytoskeleton Organization Glutamatergic Synapse Cytoskeleton Actin Filament Binding Structural Constituent Of Cytoskeleton Site Of Double-strand Break Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Postsynapse Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cellular Component Biogenesis Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Protein Polymerization Positive Regulation Of Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Regulation Of Organelle Organization Positive Regulation Of Cell Projection Organization Cell Projection Assembly Cell Projection Regulation Of Plasma Membrane Bounded Cell Projection Organization Postsynapse Focal Adhesion
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