WASF2

Description		WASP family member 2
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GO Annotations	Cellular Component	Ruffle Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Actin Cytoskeleton Membrane Basolateral Plasma Membrane Lamellipodium SCAR Complex Protein-containing Complex Cell Projection Synapse Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase A Regulatory Subunit Binding Cadherin Binding Protein Kinase A Binding Arp2/3 Complex Binding
	Biological Process	Angiogenesis Ameboidal-type Cell Migration Neuron Migration Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Cell Motility Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis Postsynaptic Actin Cytoskeleton Organization Postsynapse Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Systolic blood pressure ( 30578418)
Interacting Genes		24 interacting genes: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1 WWP2
Entrez ID		10163
HPRD ID		05796
Ensembl ID		ENSG00000158195
Uniprot IDs		Q9Y6W5
PDB IDs		2A40
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Lamellipodium Cell Projection Organization SCAR Complex Regulation Of Lamellipodium Assembly Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Actin Filament Organization Neuron Projection Morphogenesis Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Cell Motility Regulation Of Synapse Organization Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Supramolecular Fiber Organization Endocytosis Actin-based Cell Projection Positive Regulation Of Cytoskeleton Organization Arp2/3 Protein Complex Cell Projection Cytoskeleton Organization Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Postsynapse Peptidyl-tyrosine Phosphorylation Regulation Of Cell Projection Assembly Regulation Of Actin Filament Polymerization Actin Filament-based Process Identical Protein Binding Import Into Cell Cell Leading Edge Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Neuron Projection Development Regulation Of Actin Filament Length Cell Migration Actin Cytoskeleton
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