WASF2 and DOCK1

Number of citations of the paper that reports this interaction (PMID 11773052)
6

Data Source:
HPRD (in vivo, in vitro)

		WASF2	DOCK1
Gene Name		WAS protein family, member 2	dedicator of cytokinesis 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Intracellular Early Endosome Cytosol Cell-cell Junction Actin Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Actin Binding Protein Binding Protein Complex Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Angiogenesis Ameboidal-type Cell Migration Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis	Hematopoietic Progenitor Cell Differentiation Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Axon guidance Signaling by VEGF DCC mediated attractive signaling Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Netrin-1 signaling VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Apolipoprotein Levels ( 23031429)
Protein-Protein Interactions		23 interactors: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1	8 interactors: BCAR1 CRK ELMO1 ELMO2 NCK2 RAC1 RHOG WASF2
Entrez ID		10163	1793
HPRD ID		05796	03240
Ensembl ID		ENSG00000158195	ENSG00000150760
Uniprot IDs		Q9Y6W5	Q14185
PDB IDs		2A40	3L4C
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Vesicle-mediated Transport Neuron Projection Development Cell Projection Morphogenesis Neuron Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Neuron Development Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament Organization Cell Morphogenesis Defense Response Neuron Differentiation Cell Development Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Immune System Process Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Actin Filament-based Process Generation Of Neurons Locomotion Cell Morphogenesis Involved In Differentiation Neurogenesis Immune System Process Cytoskeleton Organization Chemotaxis Nervous System Development Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization	Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Actin Cytoskeleton Organization Phagocytosis Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Actin Filament-based Process Regulation Of Immune System Process Rac Protein Signal Transduction Movement Of Cell Or Subcellular Component Cell Migration Regulation Of Immune Response Cell Motility Cell Chemotaxis Platelet Activation Cytoskeleton Organization Lamellipodium Assembly Immune System Process Lamellipodium Organization Chemotaxis Locomotion Endocytosis Cell Activation Innate Immune Response Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Blood Coagulation Regulation Of Cell Projection Assembly Hemostasis Regulation Of Cellular Component Organization Phagocytosis, Engulfment Response To Stress Positive Regulation Of Lamellipodium Assembly Signaling Cell Communication Regulation Of Cytoskeleton Organization Membrane Invagination Positive Regulation Of Lamellipodium Organization Regulation Of Body Fluid Levels
Tagcloud ?			adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected
Tagcloud (Difference) ?			adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected
Tagcloud (Intersection) ?