WASF2 and NCKAP1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		WASF2	NCKAP1
Description		WASP family member 2	NCK associated protein 1
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Actin Cytoskeleton Membrane Basolateral Plasma Membrane Lamellipodium SCAR Complex Protein-containing Complex Cell Projection Synapse Extracellular Exosome	Ruffle Cytosol Plasma Membrane Focal Adhesion Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Cell Projection Extracellular Exosome Postsynapse
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase A Regulatory Subunit Binding Cadherin Binding Protein Kinase A Binding Arp2/3 Complex Binding	Protein Binding Small GTPase Binding
	Biological Process	Angiogenesis Ameboidal-type Cell Migration Neuron Migration Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Cell Motility Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis Postsynaptic Actin Cytoskeleton Organization Postsynapse Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cell Morphogenesis In Utero Embryonic Development Somitogenesis Neural Tube Closure Apoptotic Process Zygotic Determination Of Anterior/posterior Axis, Embryo Central Nervous System Development Endoderm Development Mesodermal Cell Migration Embryonic Body Morphogenesis Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Notochord Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Protein Localization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation Basal Protein Localization Apical Protein Localization Paraxial Mesoderm Development Paraxial Mesoderm Morphogenesis Notochord Morphogenesis Embryonic Foregut Morphogenesis Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Systolic blood pressure ( 30578418)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		24 interacting genes: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1 WWP2	16 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 TMEM132D WASF1 WASF2 WEE2-AS1 YWHAG
Entrez ID		10163	10787
HPRD ID		05796	05353
Ensembl ID		ENSG00000158195	ENSG00000061676
Uniprot IDs		Q9Y6W5	A0A994J4I5 A0A994J6K9 Q9Y2A7
PDB IDs		2A40	3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Lamellipodium Cell Projection Organization SCAR Complex Regulation Of Lamellipodium Assembly Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Actin Filament Organization Neuron Projection Morphogenesis Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Cell Motility Regulation Of Synapse Organization Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Supramolecular Fiber Organization Endocytosis Actin-based Cell Projection Positive Regulation Of Cytoskeleton Organization Arp2/3 Protein Complex Cell Projection Cytoskeleton Organization Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Postsynapse Peptidyl-tyrosine Phosphorylation Regulation Of Cell Projection Assembly Regulation Of Actin Filament Polymerization Actin Filament-based Process Identical Protein Binding Import Into Cell Cell Leading Edge Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Neuron Projection Development Regulation Of Actin Filament Length Cell Migration Actin Cytoskeleton	SCAR Complex Cell Projection Morphogenesis Cell Projection Organization Lamellipodium Organization Rac Protein Signal Transduction Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Actin Nucleation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Assembly Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Intracellular Signaling Cassette Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Intracellular Signal Transduction Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Synapse Regulation Of Lamellipodium Organization Cell Projection Assembly Actin Polymerization Or Depolymerization Signal Transduction Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Cellular Component Size Positive Regulation Of Organelle Organization Arp2/3 Complex Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Polymerization Megakaryocyte Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
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