WASF2 and TCERG1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		WASF2	TCERG1
Description		WASP family member 2	transcription elongation regulator 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Actin Cytoskeleton Membrane Basolateral Plasma Membrane Lamellipodium SCAR Complex Protein-containing Complex Cell Projection Synapse Extracellular Exosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase A Regulatory Subunit Binding Cadherin Binding Protein Kinase A Binding Arp2/3 Complex Binding	Transcription Elongation Factor Activity Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase Binding
	Biological Process	Angiogenesis Ameboidal-type Cell Migration Neuron Migration Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Cell Motility Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis Postsynaptic Actin Cytoskeleton Organization Postsynapse Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Systolic blood pressure ( 30578418)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		24 interacting genes: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1 WWP2	56 interacting genes: ABI1 AURKA BARD1 CEBPA CHAF1A CHD3 CYFIP1 CYFIP2 DIAPH1 DIAPH2 DNAJB9 ESR1 EVL FANCA FANCC FMNL1 GRB2 HNRNPH1 HNRNPK HNRNPM HNRNPU HSPA1A HSPA5 HSPA8 HTT JUNB LUC7L NONO NPM1 NUDT21 PCBP1 PIAS4 POLR2A PSPC1 RNF10 RUNX1 SETDB1 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SRSF1 SUMO2 TPM4 U2AF2 UBE2I WAS WASF2 WBP4 WIPF2 WWOX
Entrez ID		10163	10915
HPRD ID		05796	10393
Ensembl ID		ENSG00000158195	ENSG00000113649
Uniprot IDs		Q9Y6W5	A0A7P0T8N8 O14776
PDB IDs		2A40	2DK7 2DOD 2DOE 2DOF 2E71 2KIQ 2KIS 2MW9 2MWA 2MWB 2MWD 2MWE 2MWF 2N4R 2N4S 2N4T 2N4U 2N4V 2N4W 2NNT 3HFH 3Q1I 4FQG 7ABF 7ABG 8Q7N 8QO9
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Lamellipodium Cell Projection Organization SCAR Complex Regulation Of Lamellipodium Assembly Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Actin Filament Organization Neuron Projection Morphogenesis Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Anatomical Structure Morphogenesis Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Cell Motility Regulation Of Synapse Organization Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Supramolecular Fiber Organization Endocytosis Actin-based Cell Projection Positive Regulation Of Cytoskeleton Organization Arp2/3 Protein Complex Cell Projection Cytoskeleton Organization Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Postsynapse Peptidyl-tyrosine Phosphorylation Regulation Of Cell Projection Assembly Regulation Of Actin Filament Polymerization Actin Filament-based Process Identical Protein Binding Import Into Cell Cell Leading Edge Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Neuron Projection Development Regulation Of Actin Filament Length Cell Migration Actin Cytoskeleton	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process RNA Binding Catalytic Step 2 Spliceosome Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Nuclear Speck Nucleoplasm U2-type Prespliceosome Assembly Nucleus Nucleic Acid Binding U2 SnRNP RNA Metabolic Process Nucleobase-containing Compound Metabolic Process U2-type Spliceosomal Complex U2-type Precatalytic Spliceosome RNA Processing Protein-containing Complex Assembly Protein-containing Complex Organization Protein-RNA Complex Assembly Paraspeckles Cellular Component Assembly MRNA Splice Site Recognition MRNA 3'-splice Site Recognition U2-type Prespliceosome Regulation Of RNA Splicing SCAR Complex Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Matrix Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Actin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Actin Polymerization Or Depolymerization Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex MRNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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