TRAP1 and TGFBR2

Number of citations of the paper that reports this interaction (PMID 11278302)
8

Data Source:
HPRD (in vivo, in vitro)

		TRAP1	TGFBR2
Gene Name		TNF receptor-associated protein 1	transforming growth factor, beta receptor II (70/80kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Lipid Particle Membrane Extracellular Vesicular Exosome	Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Poly(A) RNA Binding Unfolded Protein Binding	Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Response To Stress Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	Blood Vessel Development Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Activation Of Protein Kinase Activity Embryonic Hemopoiesis Wound Healing Regulation Of Cell Proliferation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Palate Development Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Response To Cholesterol Lens Fiber Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs			Glycerol
Diseases
GWAS		Metabolite levels (HVA/5-HIAA ratio) ( 23319000)	Breast cancer ( 23535729) Migraine ( 22683712) Tonometry ( 17903302)
Protein-Protein Interactions		14 interactors: APP ESX1 EXT1 EXT2 HGS PSMC4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	44 interactors: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CBL CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX EIF3I ENG GOPC KCNK18 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TCTEX1D4 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TSSK1B ZFYVE9
Entrez ID		10131	7048
HPRD ID		05868	01823
Ensembl ID		ENSG00000126602	ENSG00000163513
Uniprot IDs		B4DR68 F5H897 Q12931 Q53FS6	A3QNQ0 D2JYI1 P37173
PDB IDs			1KTZ 1M9Z 1PLO 2PJY 3KFD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization Signal Transduction Embryonic Morphogenesis Regulation Of Protein Phosphorylation Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Embryo Development Signaling Positive Regulation Of Metabolic Process Cell Communication Positive Regulation Of Cellular Metabolic Process Detection Of Bacterial Lipoprotein Chordate Embryonic Development Regulation Of Protein Localization Embryo Development Ending In Birth Or Egg Hatching Gastrulation Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process In Utero Embryonic Development Endothelial Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Interleukin-6 Biosynthetic Process Programmed Cell Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of SMAD Protein Import Into Nucleus Cell Death Death Detection Of Molecule Of Bacterial Origin Cellular Response To Bacterial Lipopeptide Regulation Of Protein Transport Anatomical Structure Morphogenesis Positive Regulation Of Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Regulation Of Interleukin-6 Production Pathway-restricted SMAD Protein Phosphorylation Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Proliferation Palate Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Activation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport	Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Tube Development Response To Wounding Regulation Of Cell Death Signaling Positive Regulation Of Phosphorylation Regulation Of Cell Differentiation Cellular Response To Stimulus Signal Transduction Cell Communication Response To Stress Regulation Of Gene Expression Regulation Of Apoptotic Process Tissue Morphogenesis Anatomical Structure Morphogenesis
Tagcloud ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Difference) ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Intersection) ?