TRAP1 and PTGER4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TRAP1	PTGER4
Description		TNF receptor associated protein 1	prostaglandin E receptor 4
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Intracellular Organelle Lumen	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein Kinase Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Protein Folding Translational Attenuation Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle)	Prostanoid ligand receptors G alpha (s) signalling events
Drugs			Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases
GWAS		Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 27863252 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		17 interacting genes: APP ESX1 EXT1 EXT2 FXR1 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337
Entrez ID		10131	5734
HPRD ID		05868	03350
Ensembl ID		ENSG00000126602	ENSG00000171522
Uniprot IDs		A0A140VJY2 Q12931 Q53FS6	A0PJF5 P35408
PDB IDs		4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05 7C7B 7C7C 7KCK 7KCL 7KCM 7KLU 7KLV 7U8U 7U8V 7U8W 7U8X 7ULK	5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		Membrane Raft Receptor Complex Regulation Of Inflammatory Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Defense Response Negative Regulation Of Multicellular Organismal Process N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Regulation Of Extracellular Matrix Organization Cell Activation Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity Positive Regulation Of Extracellular Matrix Organization Transforming Growth Factor Beta Ligand-receptor Complex Microglial Cell Activation Activin Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Mesenchymal Cell Differentiation Leukocyte Activation Involved In Inflammatory Response Regulation Of Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Myeloid Leukocyte Activation Ventricular Septum Morphogenesis Chondrocyte Hypertrophy Animal Organ Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Gene Expression Endochondral Bone Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Multicellular Organismal Process Gastrulation SMAD Binding Protein Heterodimerization Activity Heparin Proteoglycan Biosynthetic Process Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Sebaceous Gland Development Transforming Growth Factor Beta Receptor Activity Lipopeptide Binding Developmental Process Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition	Heme Oxidation Heme Oxygenase (decyclizing) Activity
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